Process for the preparation of cyclic enamides

Claim 2

A process for the preparation of a cyclic enamide of the formula ##STR15## in which R 1 is a single bond or alkylene of from 1 to 8 carbon atoms ##STR16## p1 in which the carbon atom carrying the CH 3 or the oxygen radical is bound to the ring nitrogen atom: R 3 is a hydrogen atom, secondary or tertiary alkyl of 3 or 4 carbon atoms, ##STR17## in which R 4 is alkyl of from 1 to 6 carbon atoms; phenyl; phenyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; benzyl; or benzyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; and R 4' has the same meaning as R 4 or is hydrogen; provided that either one or the other, but not both, of the radicals R 2 and R 3 contains a ##STR18## which comprises heating a cyclic amide of the formula ##STR19## in which R 1 and R 3 are as defined previously, and R 2' is ##STR20## the carbon atom carrying the CH 3 , O or OR 5 radical being bound to the ring nitrogen atom and R 5 being a primary or secondary alkyl of from 1 to 4 carbon atoms, provided that either one or the other, but not both, of the radicals R 2' and R 3 contains a ##STR21## to a temperature of from about 100° to 250° C., in the presence of a catalyst selected from the group consisting of tetraalkylammonium salts of tetrafluoroboric acid, alkali metal salts of tetafluoroboric acid, tetraalkylammonium salts of hexafluorophosphoric acid and alkali metal salts of hexafluorophosphoric acid, and mixtures thereof, distilling off the detached alcohol R 5 OH, and isolating the enamide.

Claim 3

A process as claimed in claim 1, which further comprises producing a cyclic amide by anodically alkoxylating a cyclic nitrogen compound of the formula ##STR22## R 1 and R 3 being as defined previously and R 2" being ##STR23## the carbon atom carrying the CH 3 or the oxygen radical being bound to the ring nitrogen atom, provided that either one or the other, but not both, of the radicals R 2" and R 3 contains a ##STR24## in an alcohol R 5 OH, R 5 being as defined previously, in the presence of a supporting electrolyte which is selected from the group consisting of tetraalkylammonium salts of tetrafluoroboric acid, alkali metal salts of tetrafluoroboric acid, tetraalkylammonium salts of hexafluorophosphoric acid and alkali metal salts of hexafluorophosphoric acid, and mixtures thereof, heating the cyclic amide in the presence of a catalyst which is identical with said electrolyte, and distilling off the alcohol R 5 OH.

Claim 4

A process for the preparation of a cyclic enamide of the formula ##STR25## in which R 1 is a single bond or alkylene of from 1 to 8 carbon atoms; ##STR26## in which the carbon atom carrying the CH 3 or the oxygen radical is bound to the ring nitrogen atom; R 3 is a hydrogen atom, second or tertiary alkyl of 3 or 4 carbon atoms, ##STR27## in which R 4 is alkyl of from 1 to 6 carbon atoms; phenyl; phenyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; benzyl; or benzyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; and R 4' has the same meaning as R 4 or is hydrogen; provided that either one or the other, but not both, of the radicals R 2 and R 3 contains ##STR28## which consists of heating a cyclic amide of the formula ##STR29## in which R 1 and R 3 are as defined previously, and R 2' is ##STR30## the carbon atom carrying the CH 3 , O or OR 5 radical being bound to the ring nitrogen atom and R 5 being a primary or secondary alkyl of from 1 to 4 carbon atoms, provided that either one or the other, but not both, of the radicals R 2' and R 3 contains a ##STR31## to a temperature of from about 100° to 250° C., in the presence of a catalyst selected from the group consisting of tetraalkylammonium salts of tetrafluoroboric acid, alkali metal salts of tetrafluoroboric acid, tetraalkylammonium salts of hexafluorophoric acid and alkali metal salts of hexafluorophosphoric acid, and mixtures thereof, distilling off the detached alcohol R 5 OH, and isolating the enamide.

Claim 5

A process for the preparation of a cyclic enamide of the formula ##STR25## in which R 1 is a single bond or alkylene of from 1 to 8 carbon atoms; ##STR26## in which the carbon atom carrying the CH 3 or the oxygen radical is bound to the ring nitrogen atom; R 3 is a hydrogen atom, second or tertiary alkyl of 3 or 4 carbon atoms, ##STR27## in which R 4 is alkyl of from 1 to 6 carbon atoms; phenyl; phenyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; benzyl; or benzyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; and R 4' has the same meaning as R 4 or is hydrogen; provided that either one or the other, but not both, of the radicals R 2 and R 3 contains ##STR28## which consists of heating a cyclic amide of the formula ##STR29## in which R 1 and R 3 are as defined previously, and R 2' is ##STR30## the carbon atom carrying the CH 3 , O or OR 5 radical being bound to the ring nitrogen atom and R 5 being a primary or secondary alkyl of from 1 to 4 carbon atoms, provided that either one or the other, but not both, of the radicals R 2' and R 3 contains a ##STR31## to a temperature of from about 100° to 250° C., in the presence of a catalyst selected from the group consisting of tetraalkylammonium salts of tetrafluoroboric acid, alkali metal salts of tetrafluoroboric acid, tetraalkylammonium salts of hexafluorophoric acid and alkali metal salts of hexafluorophosphoric acid, and mixtures thereof, distilling off the detached alcohol R 5 OH, and isolating the enamide.

Claim 6

A process for the preparation of a cyclic enamide of the formula ##STR32## in which R 1 is a single bond or alkylene of from 1 to 8 carbon atoms R 2 is ##STR33## in which the carbon atom carrying the CH 3 or the oxygen radical is bound to the ring nitrogen atom; R 3 is a hydrogen atom, secondary or tertiary alkyl of 3 or 4 carbon atoms, ##STR34## in which R 4 is alkyl of from 1 to 6 carbon atoms; phenyl; phenyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; benzyl; or benzyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; and R 4' has the same meaning as R 4 or is hydrogen; provided that either one or the other, but not both, of the radicals R 2 and R 3 contains a ##STR35## which consists of anodically alkoxylating a cyclic nitrogen compound of the formula ##STR36## R 1 and R 3 being as defined previously and R 2" being ##STR37## the carbon atom carrying the CH 3 or the oxygen radical being bound to the ring nitrogen atom; provided that either one or the other, but not both, of the radicals R 2" and R 3 contains a ##STR38## in an alcohol R 5 OH, R 5 being as defined previously, in the presence of a supporting electrolyte which is selected from the group consisting of tetraalkylammonium salts of tetrafluoroboric acid, alkali metal salts of tetrafluoroboric acid, tetraalkylammonium salts of hexafluorophosphoric acid and alkalia metal salts of hexafluorophosphoric acid, and mixtures thereof, to produce a cyclic amide of the formula ##STR39## in which R 1 and R 3 are as defined previously, R 2' is ##STR40## the carbon atom carrying the CH 3 , O or OR 5 radical being bound to the ring nitrogen atom and R 5 being a primary or secondary alkyl of from 1 to 4 carbon atoms, provided that either one or the other, but not both of the radicals R 2' and R 3 contains a ##STR41## and heating the cyclic amide to a temperature of from about 100° to 250° C., in the presence of a catalyst which is identical with said electrolyte, distilling off the detached alcohol R 5 OH, and isolating the enamide.

Claim 7

A process for the preparation of a cyclic enamide of the formula ##STR32## in which R 1 is a single bond or alkylene of from 1 to 8 carbon atoms R 2 is ##STR33## in which the carbon atom carrying the CH 3 or the oxygen radical is bound to the ring nitrogen atom; R 3 is a hydrogen atom, secondary or tertiary alkyl of 3 or 4 carbon atoms, ##STR34## in which R 4 is alkyl of from 1 to 6 carbon atoms; phenyl; phenyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; benzyl; or benzyl substituted by at least one member of the group consisting of alkyls of from 1 to 4 carbon atoms, fluorine, chlorine and bromine; and R 4' has the same meaning as R 4 or is hydrogen; provided that either one or the other, but not both, of the radicals R 2 and R 3 contains a ##STR35## which consists of anodically alkoxylating a cyclic nitrogen compound of the formula ##STR36## R 1 and R 3 being as defined previously and R 2" being ##STR37## the carbon atom carrying the CH 3 or the oxygen radical being bound to the ring nitrogen atom; provided that either one or the other, but not both, of the radicals R 2" and R 3 contains a ##STR38## in an alcohol R 5 OH, R 5 being as defined previously, in the presence of a supporting electrolyte which is selected from the group consisting of tetraalkylammonium salts of tetrafluoroboric acid, alkali metal salts of tetrafluoroboric acid, tetraalkylammonium salts of hexafluorophosphoric acid and alkalia metal salts of hexafluorophosphoric acid, and mixtures thereof, to produce a cyclic amide of the formula ##STR39## in which R 1 and R 3 are as defined previously, R 2' is ##STR40## the carbon atom carrying the CH 3 , O or OR 5 radical being bound to the ring nitrogen atom and R 5 being a primary or secondary alkyl of from 1 to 4 carbon atoms, provided that either one or the other, but not both of the radicals R 2' and R 3 contains a ##STR41## and heating the cyclic amide to a temperature of from about 100° to 250° C., in the presence of a catalyst which is identical with said electrolyte, distilling off the detached alcohol R 5 OH, and isolating the enamide.

Claim 8

A process as defined in claim 1, wherein the cyclic amide is mixed with the catalyst in the presence of a solvent which is subsequently distilled off.

Claim 9

A process as claimed in claim 1, 2, or 5, wherein the cyclic amide, if R 2' is ##STR42## R 1 is branched or linear alkylene of from 1 to 8 carbonatoms and, if R 2' is ##STR43## R 1 is a single bond or a branched or linear alkylene group of from 1 to 3 carbon atoms.

Claim 10

A process as claimed in claim 6, wherein in the cyclic amide R 4 is CH 3 , C 2 H 5 , C 6 H 5 , C 6 H 5 CH 2 , substituted C 6 H 5 or substituted C 6 H 5 CH 2 and R 4' is CH 3 , C 2 H 5 , C 6 H 5 , C 6 H 5 CH 2 , substituted C 6 N 5 , substituted C 6 H 5 CH 2 or H and R 5 is CH 3 .

Claim 11

A process as claimed in claim 7 wherein the catalyst is sodium tetrafluoroborate, potassium tetrafluoroborate, sodium hexafluorophosphate, potassium hexafluorophosphate, or a mixture thereof.

Claim 12

A process as claimed inn claim 8, wherein the catalyst is present in an amount of from about 0.1 to 20% by weight, calculated on the cyclic amide.

Claim 13

A process as claimed in claim 9, wherein the cyclic amide is heated in the presence of the catalyst to a temperature of from about 120° to 180° C.

Claim 14

A process as claimed in claim 10, wherein the cyclic amide is heated at reduced pressure.

Claim 15

A process as claimed in claim 11, wherein R 4 and R 4' are phenyl or benzyl is substituted by 1 or 2 of said members.

Claim 16

A process as claimed in claim 1, 2 or 5 wherein in the cyclic amide R 4 is CH 3 , C 2 H 5 , C 6 H 5 , C 6 H 5 CH 2 , substituted C 6 H 5 or substituted C 6 H 5 CH 2 and R 4' is CH 3 , C 2 H 5 , C 6 H 5 , C 6 H 5 CH 2 , substituted C 6 H 5 , substituted C 6 H 5 CH 2 or H and R 5 is CH 3 .

Claim 17

A process as claimed in claim 1, 2 or 5 wherein the catalyst is sodium tetrafluoroborate, potassium tetrafluoroborate, sodium hexafluorophosphate, potassium hexafluorolphosphate, or a mixture thereof.

Claim 18

A process as claimed in claim 1, 2 or 5, wherein the catalyst is present in an amount of from about 0.1 to 20% by weight, calculated on the cyclic amide.

Claim 19

A process as claimed in claim 1, 2 or 5 wherein the cyclic amide is heated in the presence of the catalyst to a temperature of from about 120° to 180° C.

Claim 20

A process as claimed in claim 1, 2 or 5 wherein the cyclic amide is heated at reduced pressure.

Claim 21

A process as defined in claim 1, 2 or 5 wherein R 4 and R 4' are phenyl or benzyl substituted by 1 or 2 of said members.