US4235778A
Expired / Lapsed
US
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2-Pyrrolidone compounds and processes for making same
Assignee: Merrell Toraude et Cie
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Filing: 1979-06-04
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Granted: 1980-11-25
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Expires: 1999-06-04
Abstract
Abstract Novel compounds of the following general formula are useful in the preparation of 4-aminohex-5-enoic acid and 4-aminohex-5-ynoic acid which are useful pharmacological agents: ##STR1## wherein R 1 is hydroxy, amino, or tert-butoxy.
Inventors
- 👤 Maurice W. Gittos
- 👤 Gerard J. Letertre
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 15:01
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/18; C07D207/22; C07D207/24; C07D207/26; C07D207/273; C07D207/277; C07D319/00; C07D319/04; C07D319/08
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
31 words
A compound of the formula ##STR11## wherein R 1 is hydroxy, amino, or tertiary-butoxy, and the alkali metal, alkaline earth metal and organic amine salts thereof when R 1 is hydroxy.
Claim 2
Dependent Claim
31 words
A compound of the formula ##STR11## wherein R 1 is hydroxy, amino, or tertiary-butoxy, and the alkali metal, alkaline earth metal and organic amine salts thereof when R 1 is hydroxy.
Claim 3
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is hydroxy.
Claim 4
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is amino.
Claim 5
Dependent Claim
154 words
A process for the preparation of a compound of claim 1 which comprises reacting a 2-vinylcyclopropane-1,1-dicarboxylic acid derivative of the formula ##STR12## with ammonia gas in an appropriate inert polar solvent at a temperature of about 25° to 150° C. for about 4 to 24 hours wherein each of R 2 and R 3 are different and represent a straight or branched alkoxy group of from 1 to 4 carbon atoms, or R 2 and R 3 are the same and represent a straight or branched alkoxy group having from 1 to 6 carbon atoms or a straight or branched alkenyloxy group having from 2 to 4 carbon atoms or R 2 and R 3 taken together form a lower alkylenedioxo group of the structure ##STR13## wherein each of R 4 and R 5 may be the same or different and represents a straight chain alkyl group having from 1 to 4 carbon atoms.
References Cited (Backward Citations)
US4178463A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |