Patent US4235877A successfully refreshed from Google Patents.
US4235877A
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Liposome particle containing viral or bacterial antigenic subunit
Assignee: Merck and Co Inc
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Filing: 1979-06-27
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Granted: 1980-11-25
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Expires: 1999-06-27
Abstract
Abstract Subunit viral or bacterial antigens are incorporated into liposomes containing a positively charged amino-containing surfactant. The resulting complex is antigenically more active than the free antigen.
Inventors
- 👤 William W. Fullerton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:33
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K39/12; A61K39/145; A61K39/29; A61K39/292; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K2039/555; A61K2039/55511; A61K2039/55555; C; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10134; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134; Y; Y10; Y10S; Y10S424/00; Y10S424/812
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
102 words
A particle comprising a liposome, a positively charged quaternary ammonium salt of an amino-containing surfactant of the formulas ##STR2## wherein R 1 is a straight or branched chain alkyl radical of from 12 to 20 carbon atoms, R 2 and R 3 may be the same or different and are alkyl of from 1 to 3 carbon atoms, and R 4 is benzyl, R 5 and R 6 together are a 5-membered or 6-membered heterocyclic radical, and X is a halide ion, preferably chloride or bromide, and a viral or bacterial subunit antigen reacted therewith to form a complex which complex is.
Claim 2
Dependent Claim
102 words
A particle comprising a liposome, a positively charged quaternary ammonium salt of an amino-containing surfactant of the formulas ##STR2## wherein R 1 is a straight or branched chain alkyl radical of from 12 to 20 carbon atoms, R 2 and R 3 may be the same or different and are alkyl of from 1 to 3 carbon atoms, and R 4 is benzyl, R 5 and R 6 together are a 5-membered or 6-membered heterocyclic radical, and X is a halide ion, preferably chloride or bromide, and a viral or bacterial subunit antigen reacted therewith to form a complex which complex is.
Claim 3
Dependent Claim
15 words
A particle according to claim 1 wherein the liposome is formed from a phosphatidylcholine-containing lipid.
Claim 4
Dependent Claim
27 words
A particle according to claim 1 wherein the subunit antigen is derived from influenza virus, hepatitis B virus, N. gonorrhoeae, or Meningococcus polysaccharide types A or C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |