Patent US4258152A successfully refreshed from Google Patents.
US4258152A
Expired / Lapsed
US
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Pentapeptide modified resin
Assignee: Memorial Sloan Kettering Cancer Center
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Filing: 1979-06-12
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Granted: 1981-03-24
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Expires: 1999-06-12
Abstract
Abstract There are disclosed polypeptide compositions having the following amino acid sequence as the active site: ARG-LYS-ASP-VAL-TYR These polypeptides have the capability of inducing the differentiation of T-lymphocytes but not of complement receptor (CR+) B-lymphocytes and thus are useful in a number of therapeutic areas. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.
Inventors
- 👤 Gideon Goldstein
- 👤 David H. Schlesinger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 05:26
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06034; C07K5/06052; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
119 words
An intermediate polypeptide of the following sequence: ##STR5## wherein R 1 , R 2 , R 3 , R 4 and R 5 are protecting groups with R 1 , R 2 , R 3 and R 4 being protecting groups on reactive side chains, and wherein the R 5 protecting group is on an amino group of the ARG amino acid and is removable under conditions which do not affect the R 1 , R 2 , R 3 and R 4 groups, and the resin is an insoluble polymer having a stable physical form and is attached to a carboxyl group of the TYR amino acid through a functional group of the resin by a covalent bond.
Claim 2
Dependent Claim
119 words
An intermediate polypeptide of the following sequence: ##STR5## wherein R 1 , R 2 , R 3 , R 4 and R 5 are protecting groups with R 1 , R 2 , R 3 and R 4 being protecting groups on reactive side chains, and wherein the R 5 protecting group is on an amino group of the ARG amino acid and is removable under conditions which do not affect the R 1 , R 2 , R 3 and R 4 groups, and the resin is an insoluble polymer having a stable physical form and is attached to a carboxyl group of the TYR amino acid through a functional group of the resin by a covalent bond.
Claim 3
Dependent Claim
30 words
An intermediate polypeptide according to claim 1 wherein R 1 is tosyl, R 2 is ε-2-chlorobenzyloxycarbonyl, R 3 is benzyl, R 4 is O-2,6-dichlorobenzyl, and R 5 is amyloxy carbonyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-23 | 1984-09-22 | 1985-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-23 | 1988-09-22 | 1989-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-23 | 1992-09-22 | 1993-03-24 | $7700.00 | Window Closed / Lapsed |