Patent US4309340A successfully refreshed from Google Patents.
US4309340A
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Polypeptide compositions
Assignee: Wyeth LLC
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Filing: 1980-03-31
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Granted: 1982-01-05
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Expires: 2000-03-31
Abstract
Abstract There are disclosed polypeptides having the following formula: R-X.sub.1 -Lys-X.sub.3 -Val-X.sub.5 -R.sub.1 wherein R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms; X 1 is L-Arg, D-Arg or D-homoarginine; X 3 is Asn, Gln or the N-substituted carboxamides thereof; X 5 is L- or D-Tyr, L- or D-Phe, L- or D-Trp, L- or D-Leu, L- or D-Met, D-Met-ol-oxide or D-Phe-ol; and R 1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR1## the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof. These polypeptides have the capability of inducing the differentiation of T-lymphocytes and thus are useful in a number of therapeutic areas.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 21:30
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/66; C07K14/662; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/18; Y10S930/28
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
97 words
A polypeptide having the following formula: R-X.sub.1 -Lys-X.sub.3 -Val-X.sub.5 -R.sub.1 wherein R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms; X 1 is L-Arg, D-Arg or D-homoarginine; X 3 is Asn, Gln or the N-substituted carboxamides thereof; X 5 is L- or D-Tyr, L- or D-Phe, L- or D-Trp, L- or D-Leu, L- or D-Met, D-Met-ol-oxide or D-Phe-ol; and R 1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR5## or the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
97 words
A polypeptide having the following formula: R-X.sub.1 -Lys-X.sub.3 -Val-X.sub.5 -R.sub.1 wherein R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms; X 1 is L-Arg, D-Arg or D-homoarginine; X 3 is Asn, Gln or the N-substituted carboxamides thereof; X 5 is L- or D-Tyr, L- or D-Phe, L- or D-Trp, L- or D-Leu, L- or D-Met, D-Met-ol-oxide or D-Phe-ol; and R 1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR5## or the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
94 words
A polypeptide having the following formula: R-X.sub.1 -Lys-X.sub.3 -Val-X.sub.5 -R.sub.1 wherein R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms; X 1 is L-Arg, D-Arg or D-homoarginine; X 3 is Asn, Gln or the N-substituted carboxamides thereof; X 5 is L- or D-Phe, L- or D-Trp, L- or D-Leu, L- or D-Met, D-Met-ol-oxide or D-Phe-ol; and R 1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR6## or the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
94 words
A polypeptide having the following formula: R-X.sub.1 -Lys-X.sub.3 -Val-X.sub.5 -R.sub.1 wherein R is hydrogen, alkanoyl of 1-4 carbon atoms or aroyl of 6-10 carbon atoms; X 1 is L-Arg, D-Arg or D-homoarginine; X 3 is Asn, Gln or the N-substituted carboxamides thereof; X 5 is L- or D-Phe, L- or D-Trp, L- or D-Leu, L- or D-Met, D-Met-ol-oxide or D-Phe-ol; and R 1 is amino, monoalkylamino of 1-4 carbon atoms, dialkylamino of 1-4 carbon atoms, hydroxy, alkoxy of 1-4 carbon atoms, ##STR6## or the fully protected peptide-resin intermediates thereof, or pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
15 words
The compound of claim 1, which is Arg-Lys-Asn-Val-Tyr-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
14 words
The compound of claim 1, which is D-Arg-Lys-Asn-Val-D-Phe-NH 2 or a pharmaceutically salt thereof.
References Cited (Backward Citations)
US4190646A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1985-01-04 | 1985-07-06 | 1986-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-01-04 | 1989-07-06 | 1990-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-01-04 | 1993-07-06 | 1994-01-05 | $7700.00 | Window Closed / Lapsed |