Patent US4325945A successfully refreshed from Google Patents.
US4325945A
Expired / Lapsed
US
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Mixed disulfides
Assignee: ER Squibb and Sons LLC
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Filing: 1980-12-22
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Granted: 1982-04-20
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Expires: 2000-12-22
Abstract
Abstract This invention is directed to compounds of the formula ##STR1## wherein A and A 1 are amino acid residues, X is an α-imino acid residue, and R 1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
Inventors
- 👤 Sesha I. Natarajan
- 👤 Miguel A. Ondetti
- 👤 Shih-jung Lan
- 👤 Keith K. Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:39
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0215; A; A61; A61P; A61P7/00; A61P7/10; A61P9/00; A61P9/12; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/80
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
107 words
A compound of the formula ##STR43## and salts thereof, wherein A and A 1 are each amino acid residues independently selected from the group consisting of glycyl, alanyl, valyl, leucyl, α-glutamyl, γ-glutamyl, α-aspartyl, β-aspartyl, phenylalanyl, tyrosyl, lysyl, arginyl, and prolyl, said A residue being joined through a carbonyl group and said A 1 residue being joined through an amino group; R 1 is hydrogen, lower alkyl or halo substituted lower alkyl; X is an α-imino acid residue selected from the group consisting of ##STR44## R 3 , R 4 , R 8 and R 9 are independently selected from the group consisting of hydrogen and lower alkyl.
Claim 2
Dependent Claim
107 words
A compound of the formula ##STR43## and salts thereof, wherein A and A 1 are each amino acid residues independently selected from the group consisting of glycyl, alanyl, valyl, leucyl, α-glutamyl, γ-glutamyl, α-aspartyl, β-aspartyl, phenylalanyl, tyrosyl, lysyl, arginyl, and prolyl, said A residue being joined through a carbonyl group and said A 1 residue being joined through an amino group; R 1 is hydrogen, lower alkyl or halo substituted lower alkyl; X is an α-imino acid residue selected from the group consisting of ##STR44## R 3 , R 4 , R 8 and R 9 are independently selected from the group consisting of hydrogen and lower alkyl.
Claim 3
Dependent Claim
9 words
The composition of claim 1 also including a diuretic.
Claim 4
Dependent Claim
17 words
The method of alleviating hypertension which comprises administering an effective amount of the composition of claim 1.
Claim 5
Dependent Claim
25 words
A compound of claim 1 wherein R 1 is hydrogen, methyl, or trifluoromethyl; A is γ-glutamyl; A 1 is glycyl; and X is (L)-thiazolidine-4-carboxylic acid.
Claim 6
Dependent Claim
10 words
The compound of claim 4 wherein R 1 is methyl.
Claim 7
Dependent Claim
126 words
A composition for treating hypertension comprising a pharmaceutically acceptable carrier and an effective amount of one or more hypotensive agents or pharmaceutically acceptable salts thereof of the formula ##STR45## wherein A and A 1 are each amino acid residues independently selected from the group consisting of glycyl, alanyl, valyl, leucyl, α-glutamyl, α-aspartyl, β-aspartyl, phenylalanyl, tyrosyl, lysyl, arginyl, and prolyl, said A residue being joined through a carbonyl group and said A 1 residue being joined through an amino group; R 1 is hydrogen, lower alkyl or halo substituted lower alkyl; X is an α-imino acid residue selected from the group consisting of ##STR46## R 3 , R 4 , R 8 and R 9 are independently selected from the group consisting of hydrogen and lower alkyl.
Claim 8
Dependent Claim
126 words
A composition for treating hypertension comprising a pharmaceutically acceptable carrier and an effective amount of one or more hypotensive agents or pharmaceutically acceptable salts thereof of the formula ##STR45## wherein A and A 1 are each amino acid residues independently selected from the group consisting of glycyl, alanyl, valyl, leucyl, α-glutamyl, α-aspartyl, β-aspartyl, phenylalanyl, tyrosyl, lysyl, arginyl, and prolyl, said A residue being joined through a carbonyl group and said A 1 residue being joined through an amino group; R 1 is hydrogen, lower alkyl or halo substituted lower alkyl; X is an α-imino acid residue selected from the group consisting of ##STR46## R 3 , R 4 , R 8 and R 9 are independently selected from the group consisting of hydrogen and lower alkyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-19 | 1985-10-19 | 1986-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-19 | 1989-10-19 | 1990-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-19 | 1993-10-19 | 1994-04-20 | $7700.00 | Window Closed / Lapsed |