Patent US4329355A successfully refreshed from Google Patents.
US4329355A
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US
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Mesoionic antitumor compositions and methods for using the same in the treatment of cancer
Assignee: Individual
•
Filing: 1979-03-01
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Granted: 1982-05-11
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Expires: 1999-03-01
Abstract
Abstract Mesoionic anhydro-5-amino-1,2,3,4-oxatriazolium hydroxides and methods of using the same in the treatment of cancer, said compositions containing, as an active ingredient, one or more compounds having the structure ##STR1## wherein R 1 represents a phenyl or substituted phenyl group and R 2 represents hydrogen or a methyl group.
Inventors
- 👤 David W. Henry
- 👤 Kenneth J. Ryan
- 👤 Edward W. Grange
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 06:44
CPC Classifications
C; C07; C07D; C07D273/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
65 words
A process for treating leukemia which comprises administering to a warm-blooded animal having an abnormal proportion of leukocytes an effective amount for treating leukemia of a compound selected from the group having the structure ##STR4## wherein R 1 represents phenyl or phenyl substituted by methyl, nitro or chloro groups, and wherein R 2 represents hydrogen or a methyl group, together with their pharmaceutically acceptable salts.
Claim 2
Dependent Claim
65 words
A process for treating leukemia which comprises administering to a warm-blooded animal having an abnormal proportion of leukocytes an effective amount for treating leukemia of a compound selected from the group having the structure ##STR4## wherein R 1 represents phenyl or phenyl substituted by methyl, nitro or chloro groups, and wherein R 2 represents hydrogen or a methyl group, together with their pharmaceutically acceptable salts.
Claim 3
Dependent Claim
32 words
A process according to claim 1 in which the compound is administered in an effective amount for treating leukemia within a range of from about 0.1 to about 500 mg per day.
Claim 4
Dependent Claim
17 words
The process of claim 2 wherein the compound administered to the warm-blooded animal is anhydro-5-methylamino-3-phenyl-1,2,3,4-oxatriazolium hydroxide hydrochloride.
Claim 5
Dependent Claim
17 words
The process of claim 2 wherein the compound administered to the warm-blooded animal is anhydro-5-amino-3-(m-tolyl)-1,2,3,4,-oxatriazolium hydroxide hydrochloride.
Claim 6
Dependent Claim
17 words
The process of claim 2 wherein the compound administered to the warm-blooded animal is anhydro-5-amino-3-(m-nitrophenyl)-1,2,3,4-oxatriazolium hydroxide hydrochloride.
Claim 7
Dependent Claim
17 words
The process of claim 2 wherein the compound administered to the warm-blooded animal is anhydro-5-amino-3-phenyl-1,2,3,4-oxatriazolium hydroxide hydrochloride.
Claim 8
Dependent Claim
17 words
The process of claim 2 wherein the compound administered to the warm-blooded animal is anhydro-5-amino-3-(p-chlorophenyl)-1,2,3,4,-oxatriazolium hydroxide hydrochloride.
Claim 9
Dependent Claim
17 words
The process of claim 2 wherein the compound administered to the warm-blooded animal is anhydro-5-amino-3-(o-tolyl)-1,2,3,4,-oxatriazolium hydroxide hydrochloride.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-10 | 1985-11-09 | 1986-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-10 | 1989-11-09 | 1990-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-10 | 1993-11-09 | 1994-05-11 | $7700.00 | Window Closed / Lapsed |