Dentifrices with improved soluble fluoride availability

Claim 2

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective abrasive amount of calcium carbonate and from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate, said dentifrice being devoid of benzyl alcohol.

Claim 3

The dentifrice of claim 1 wherein said monofluorophosphate salt is sodium monofluorophosphate.

Claim 4

The dentifrice of claim 1 wherein said dibasic alkali metal phosphate is dibasic sodium phosphate.

Claim 5

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective abrasive amount of calcium carbonate, from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate and from about 0.1 to about 1.0 percent by weight of a calcium ion chelator, said dentifrice being devoid of benzyl alcohol.

Claim 6

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective abrasive amount of calcium carbonate, from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate and from about 0.1 to about 1.0 percent by weight of a calcium ion chelator, said dentifrice being devoid of benzyl alcohol.

Claim 7

The dentifrice of claim 4 wherein said monofluorophosphate salt is sodium monofluorophosphate and said dibasic alkali metal phosphate is dibasic sodium phosphate.

Claim 8

The dentifrice of claim 4 wherein said calcium ion chelator is sodium hexametaphosphate or tetrasodium ethylenediamine tetraacetate.

Claim 9

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective abrasive amount of calcium carbonate, and, as the sole component for increasing retention of said monofluorophosphte as a source of soluble fluoride, from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate, said dentifrice being devoid of benzyl alcohol.

Claim 10

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective abrasive amount of calcium carbonate, and, as the sole component for increasing retention of said monofluorophosphte as a source of soluble fluoride, from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate, said dentifrice being devoid of benzyl alcohol.

Claim 11

The dentifrice of claim 7 wherein said monofluorophosphate salt is sodium monofluorophosphate.

Claim 12

The dentifrice of claim 7 wherein said dibasic alkali metal phosphate is dibasic sodium phosphate.

Claim 13

The dentifrice of claim 7 to which is added from about 0.1 to about 1.0 percent by weight of a calcium ion chelator.

Claim 14

The dentifrice of claim 7 to which is added from about 0.1 to about 1.0 percent by weight of sodium hexametaphosphate or tetrasodium ethylenediamine tetraacetate.

Claim 15

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate and from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate as the sole component for increasing retention of said monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 16

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate and from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate as the sole component for increasing retention of said monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 17

The dentifrice of claim 12 wherein said monofluorophosphate salt is an alkali metal monofluorophosphate.

Claim 18

The dentifrice of claim 12 wherein said monofluorophosphate salt is sodium monofluorophosphate.

Claim 19

The dentifrice of claim 12 wherein said dibasic alkali metal phosphate salt is dibasic sodium phosphate.

Claim 20

A dentifrice comprising sodium monofluorophosphate as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate and from about 0.3 to about 1.0 percent by weight of a dibasic sodium phosphate as the sole component for increasing retention of said monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 21

A dentifrice comprising sodium monofluorophosphate as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate and from about 0.3 to about 1.0 percent by weight of a dibasic sodium phosphate as the sole component for increasing retention of said monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 22

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate, from about 0.1 to about 1.0 percent by weight of a calcium ion chelator and from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate as the sole component, other than said calcium ion chelator, for increasing retention of said monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 23

A dentifrice comprising a water soluble monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate, from about 0.1 to about 1.0 percent by weight of a calcium ion chelator and from about 0.3 to about 1.0 percent by weight of a dibasic alkali metal phosphate as the sole component, other than said calcium ion chelator, for increasing retention of said monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 24

The dentifrice of claim 17 wherein said monofluorophosphate salt is an alkali metal monofluorophosphate.

Claim 25

The dentifrice of claim 17 wherein said monofluorophosphate salt is sodium monofluorophosphate.

Claim 26

The dentifrice of claim 17 wherein said dibasic alkali metal phosphate is dibasic sodium phosphate.

Claim 27

The dentifrice of claim 17 wherein said calcium ion chelator is sodium hexametaphosphate.

Claim 28

The dentifrice of claim 17 wherein said calcium ion chelator is a water soluble salt of ethylenediamine tetraacetic acid.

Claim 29

The dentifrice of claim 17 wherein said calcium ion chelator is tetrasodium ethylenediamine tetraacetate.

Claim 30

A dental cream comprising sodium monofluorophosphate as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate, from about 0.1 to about 1.0 percent by weight of sodium hexametaphosphate and from about 0.3 to about 1.0 percent by weight of dibasic sodium phosphate as the sole component, other than said sodium hexametaphosphate, for increasing retention of said sodium monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 31

A dental cream comprising sodium monofluorophosphate as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate, from about 0.1 to about 1.0 percent by weight of sodium hexametaphosphate and from about 0.3 to about 1.0 percent by weight of dibasic sodium phosphate as the sole component, other than said sodium hexametaphosphate, for increasing retention of said sodium monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 32

A dental cream comprising sodium monofluorophosphate as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate, from about 0.1 to about 1.0 percent by weight of tetrasodium ethylenediamine tetraacetate and from about 0.3 to about 1.0 percent by weight of dibasic sodium phosphate as the sole component, other than said tetrasodium ethylenediamine tetraacetate, for increasing retention of said sodium monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 33

A dental cream comprising sodium monofluorophosphate as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective amount of an abrasive consisting of calcium carbonate, from about 0.1 to about 1.0 percent by weight of tetrasodium ethylenediamine tetraacetate and from about 0.3 to about 1.0 percent by weight of dibasic sodium phosphate as the sole component, other than said tetrasodium ethylenediamine tetraacetate, for increasing retention of said sodium monofluorophosphate as a source of soluble fluoride, said dentifrice being devoid of benzyl alcohol.

Claim 34

A dental cream consisting essentially of: ______________________________________ Ingredients % w/w ______________________________________ Anhydrous dibasic sodium phosphate 1.00 Sodium monofluorophosphate 0.81 Glycerin 12.25 Sodium carboxymethylcellulose 0.92 Xanthan gum 0.38 Sodium saccharin 0.23 Methylparaben 0.06 Propylparaben 0.02 Sorbitol solution (70% w/v) 9.00 Potassium nitrate 5.00 Sodium lauryl sulfate 2.10 Colloidal silica 1.00 Calcium carbonate 30.00 Flavoring 1.35 Distilled water, to make 100.00 ______________________________________

Claim 35

A dental cream consisting essentially of: ______________________________________ Ingredients % w/w ______________________________________ Anhydrous dibasic sodium phosphate 1.00 Sodium monofluorophosphate 0.81 Glycerin 12.25 Sodium carboxymethylcellulose 0.92 Xanthan gum 0.38 Sodium saccharin 0.23 Methylparaben 0.06 Propylparaben 0.02 Sorbitol solution (70% w/v) 9.00 Potassium nitrate 5.00 Sodium lauryl sulfate 2.10 Colloidal silica 1.00 Calcium carbonate 30.00 Flavoring 1.35 Distilled water, to make 100.00 ______________________________________

Claim 36

A dental cream consisting essentially of: ______________________________________ Ingredients % w/w ______________________________________ Anhydrous dibasic sodium phosphate 1.00 Sodium monofluorophosphate 0.82 Glycerin 12.50 Sodium carboxymethylcellulose 0.20 Xanthan gum 0.55 Sodium saccharin 0.20 Methylparaben 0.06 Propylparaben 0.02 Sorbitol solution (70% w/v) 12.50 Colloidal silica 1.70 Calcium carbonate 35.00 Sodium lauryl sulfate 1.50 Alcohol U.S.P. 0.50 Flavoring 1.40 Distilled water, to make 100.00 ______________________________________

Claim 37

A dental cream consisting essentially of: ______________________________________ Ingredients % w/w ______________________________________ Anhydrous dibasic sodium phosphate 1.00 Sodium monofluorophosphate 0.82 Glycerin 12.50 Sodium carboxymethylcellulose 0.20 Xanthan gum 0.55 Sodium saccharin 0.20 Methylparaben 0.06 Propylparaben 0.02 Sorbitol solution (70% w/v) 12.50 Colloidal silica 1.70 Calcium carbonate 35.00 Sodium lauryl sulfate 1.50 Alcohol U.S.P. 0.50 Flavoring 1.40 Distilled water, to make 100.00 ______________________________________