Abstract The invention provides a novel means for the administration of a therapeutically effective ingredient in the form of a rectally applicable medicament capsule, in which the otherwise unavoidable extreme variation in the absorbability of the effective ingredient among the individuals rectally treated with the capsules is minimized. It has been unexpectedly found that, when the effective ingredient is contained in the capsule in the form of a liquid medicine, the osmotic pressure of the liquid content plays a very essential role in the absorption of the effective ingredient through the rectum and the variation in the absorbability of the effective ingredient among the individuals can be minimized when the osmotic pressure of the liquid content is substantially higher than the osmotic pressure of the rectal fluid with which the capsules are contacted.
A method for the administration of a rectally absorbable, therapeutically effective ingredient which comprises inserting into the rectum through the anus a medicament capsule formed of a hard capsule shell made of an enterosoluble material selected from the group consisting of mixed esters of an alkylcellulose, a hydroxyalkylcellulose or a hydroxyalkyl alkylcellulose esterified with acidic succinyl groups and aliphatic monoacyl groups, and encapsulating a liquid content containing the rectally absorbable, therapeutically effective ingredient, the osmotic pressure of the liquid content being substantially higher than the osmotic pressure of the rectal fluid.
Claim 2
Independent Claim
91 words
A method for the administration of a rectally absorbable, therapeutically effective ingredient which comprises inserting into the rectum through the anus a medicament capsule formed of a hard capsule shell made of an enterosoluble material selected from the group consisting of mixed esters of an alkylcellulose, a hydroxyalkylcellulose or a hydroxyalkyl alkylcellulose esterified with acidic succinyl groups and aliphatic monoacyl groups, and encapsulating a liquid content containing the rectally absorbable, therapeutically effective ingredient, the osmotic pressure of the liquid content being substantially higher than the osmotic pressure of the rectal fluid.
Claim 3
Dependent Claim
20 words
The process of claim 1 wherein the liquid content has a pH value in the range from 3.0 to 4.0.