US4405718A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and composition for urobilinogen control standard
Assignee: Bayer Corp
•
Filing: 1981-07-20
•
Granted: 1983-09-20
•
Expires: 2001-07-20
Abstract
Abstract A urobilinogen control standard composition, control standard device and a method for preparing such composition are disclosed. The composition comprises a substituted indole:nonionic detergent solution which is reactive with p-diethylaminobenzaldehyde and hydrochloric acid. The composition is produced by dissolving the substituted indole in a selected nonionic detergent and diluting the solution to a predetermined level. The device is a carrier matrix impregnated with a solution of a substituted indole and a nonionic detergent.
Inventors
- 👤 Myron C. Rapkin
- 👤 David L. Tabb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:22
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/103332; Y10T436/14; Y10T436/145555; Y10T436/146666
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
130 words
A method of preparing a substantially odor-free urobilinogen-free urobilinogen control standard for use in testing for the presence of urobilinogen in a urine sample which closely simulates the properties of a urobilinogen-containing urine sample when reacted with a urobilinogen assay system, which comprises dissolving a substituted indole having the formula: ##STR2## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, in a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, and ethoxy phenol and an ethoxy fatty alcohol.
Claim 2
Independent Claim
130 words
A method of preparing a substantially odor-free urobilinogen-free urobilinogen control standard for use in testing for the presence of urobilinogen in a urine sample which closely simulates the properties of a urobilinogen-containing urine sample when reacted with a urobilinogen assay system, which comprises dissolving a substituted indole having the formula: ##STR2## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, in a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, and ethoxy phenol and an ethoxy fatty alcohol.
Claim 3
Dependent Claim
25 words
A method as claimed in claim 1 wherein the substituted indole is selected from the group consisting of 2-methylindole, 1,2-dimethylindole, 2,5-dimethylindole, 2-methyl-5-methoxy indole and 5-methoxyindole.
Claim 4
Dependent Claim
12 words
A method as claimed in claim 2 wherein the indole is 2,5-dimethylindole.
Claim 5
Dependent Claim
15 words
A method as claimed in claim 1 wherein the urobilinogen assay system is p-diethylaminobenzaldehyde-hydrochloric acid.
Claim 6
Dependent Claim
28 words
A method as claimed in claim 1 wherein after the substituted indole is dissolved in said detergent, the solution is solidified to form a solid urobilinogen control standard.
Claim 7
Dependent Claim
32 words
A method as claimed in claim 1 wherein after the substituted indole is dissolved in said detergent, the solution is solidified and added to water to form a liquid urobilinogen control standard.
Claim 8
Dependent Claim
92 words
A urobilinogen-free urobilinogen control standard which comprises a compound of the formula: ##STR3## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, with a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, an ethoxy phenol and an ethoxy fatty alcohol.
Claim 9
Dependent Claim
92 words
A urobilinogen-free urobilinogen control standard which comprises a compound of the formula: ##STR3## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, with a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, an ethoxy phenol and an ethoxy fatty alcohol.
Claim 10
Dependent Claim
33 words
A urobilinogen control standard as claimed in claim 7 wherein the nonionic detergent is selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, an ethoxy phenol and an ethoxy fatty alcohol.
Claim 11
Dependent Claim
14 words
A urobilinogen control standard as claimed in claim 8 wherein the indole is 2,5-dimethylindole.
Claim 12
Dependent Claim
18 words
A urobilinogen control standard as claimed in claim 8 wherein the indole:detergent solid solution is dissolved in water.
Claim 13
Dependent Claim
22 words
A urobilinogen-free urobilinogen control standard device which comprises a carrier and, incorporated therewith, a predetermined amount of the composition of claim 7.
References Cited (Backward Citations)
US2057948A
Cited
US2811530A
Cited
US3012040A
Cited
US3446599A
Cited
US3630680A
Cited
US3853466A
Cited
US3814586A
Cited
US3989462A
Cited
US4038031A
Cited
US4158546A
Cited
DE2926833A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |