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US4405718A
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Method and composition for urobilinogen control standard
Assignee: Bayer Corp
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Filing: 1981-07-20
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Granted: 1983-09-20
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Expires: 2001-07-20
Abstract
Abstract A urobilinogen control standard composition, control standard device and a method for preparing such composition are disclosed. The composition comprises a substituted indole:nonionic detergent solution which is reactive with p-diethylaminobenzaldehyde and hydrochloric acid. The composition is produced by dissolving the substituted indole in a selected nonionic detergent and diluting the solution to a predetermined level. The device is a carrier matrix impregnated with a solution of a substituted indole and a nonionic detergent.
Inventors
- 👤 Myron C. Rapkin
- 👤 David L. Tabb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:26
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/103332; Y10T436/14; Y10T436/145555; Y10T436/146666
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
130 words
A method of preparing a substantially odor-free urobilinogen-free urobilinogen control standard for use in testing for the presence of urobilinogen in a urine sample which closely simulates the properties of a urobilinogen-containing urine sample when reacted with a urobilinogen assay system, which comprises dissolving a substituted indole having the formula: ##STR2## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, in a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, and ethoxy phenol and an ethoxy fatty alcohol.
Claim 2
Independent Claim
130 words
A method of preparing a substantially odor-free urobilinogen-free urobilinogen control standard for use in testing for the presence of urobilinogen in a urine sample which closely simulates the properties of a urobilinogen-containing urine sample when reacted with a urobilinogen assay system, which comprises dissolving a substituted indole having the formula: ##STR2## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, in a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, and ethoxy phenol and an ethoxy fatty alcohol.
Claim 3
Dependent Claim
25 words
A method as claimed in claim 1 wherein the substituted indole is selected from the group consisting of 2-methylindole, 1,2-dimethylindole, 2,5-dimethylindole, 2-methyl-5-methoxy indole and 5-methoxyindole.
Claim 4
Dependent Claim
12 words
A method as claimed in claim 2 wherein the indole is 2,5-dimethylindole.
Claim 5
Dependent Claim
15 words
A method as claimed in claim 1 wherein the urobilinogen assay system is p-diethylaminobenzaldehyde-hydrochloric acid.
Claim 6
Dependent Claim
28 words
A method as claimed in claim 1 wherein after the substituted indole is dissolved in said detergent, the solution is solidified to form a solid urobilinogen control standard.
Claim 7
Dependent Claim
32 words
A method as claimed in claim 1 wherein after the substituted indole is dissolved in said detergent, the solution is solidified and added to water to form a liquid urobilinogen control standard.
Claim 8
Dependent Claim
92 words
A urobilinogen-free urobilinogen control standard which comprises a compound of the formula: ##STR3## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, with a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, an ethoxy phenol and an ethoxy fatty alcohol.
Claim 9
Dependent Claim
92 words
A urobilinogen-free urobilinogen control standard which comprises a compound of the formula: ##STR3## wherein R 1 and R 2 are the same or different and are H or unsubstituted C 1 -C 4 alkyl, and R 3 is H, unsubstituted C 1 -C 4 alkyl, unsubstituted C 1 -C 4 alkoxy, or halogen with the proviso that R 1 , R 2 and R 3 cannot simultaneously be hydrogen, with a nonionic detergent selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, an ethoxy phenol and an ethoxy fatty alcohol.
Claim 10
Dependent Claim
33 words
A urobilinogen control standard as claimed in claim 7 wherein the nonionic detergent is selected from the group consisting of an alkanolamide, an ethoxy alkanolamide, an ethoxy phenol and an ethoxy fatty alcohol.
Claim 11
Dependent Claim
14 words
A urobilinogen control standard as claimed in claim 8 wherein the indole is 2,5-dimethylindole.
Claim 12
Dependent Claim
18 words
A urobilinogen control standard as claimed in claim 8 wherein the indole:detergent solid solution is dissolved in water.
Claim 13
Dependent Claim
22 words
A urobilinogen-free urobilinogen control standard device which comprises a carrier and, incorporated therewith, a predetermined amount of the composition of claim 7.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |