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US4419339A
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Formulation and method of making cationic lipophilic complexes
Assignee: Bracco International BV
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Filing: 1981-08-05
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Granted: 1983-12-06
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Expires: 2001-08-05
Abstract
Abstract A method for the preparation of a technetium-99m complex having the formula [(L)299mTc(X)2](+)X(-), which comprises adding technetium-99m to a complex having the formula [(L)2M(X)2](+)X(-) and heating the mixture in the presence of a source of anion X(-), wherein each L is the same or different lipophilic ligand, each X is the same or different monovalent anionic ligand, and M is a non-toxic trivalent metal ion, is disclosed.
Inventors
- 👤 Rudi D. Neirinckx
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:47
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; C; C07; C07F; C07F13/00; C07F13/005; C07F9/00; C07F9/02; C07F9/28; C07F9/50; C07F9/5045; A61K2123/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
74 words
A method for the preparation of a technetium-99m complex having the formula [(L).sub.2.sup.99m Tc(X).sub.2 ].sup.⊕ X.sup.⊖, which comprises adding technetium-99m to a complex having the formula [(L).sub.2 M(X).sub.2 ].sup.⊕ X.sup.⊖ and heating the mixture in the presence of a source of anion X.sup.⊖, wherein each L is the same or different lipophilic ligand, each X is the same or different monovalent anionic ligand, and M is a non-toxic trivalent metal ion other than technetium.
Claim 2
Independent Claim
74 words
A method for the preparation of a technetium-99m complex having the formula [(L).sub.2.sup.99m Tc(X).sub.2 ].sup.⊕ X.sup.⊖, which comprises adding technetium-99m to a complex having the formula [(L).sub.2 M(X).sub.2 ].sup.⊕ X.sup.⊖ and heating the mixture in the presence of a source of anion X.sup.⊖, wherein each L is the same or different lipophilic ligand, each X is the same or different monovalent anionic ligand, and M is a non-toxic trivalent metal ion other than technetium.
Claim 3
Dependent Claim
20 words
A method in accordance with claim 1 additionally comprising the step of adding water, after the reaction has been completed.
Claim 4
Dependent Claim
22 words
A method in accordance with claim 1 wherein the technetium-99m is added in the form of a saline solution of pertechnetate ion.
Claim 5
Dependent Claim
11 words
A method in accordance with claim 1 wherein M is iron.
Claim 6
Dependent Claim
19 words
A method in accordance with claim 1 wherein a complexing agent is present during the heating of the mixture.
Claim 7
Dependent Claim
53 words
A method in accordance with claim 1 for the preparation of [[bis(1,2-dimethylphosphino)ethane] 2 99m Tc(Cl) 2 ].sup.⊕ Cl.sup.⊖ which comprises the addition of a saline solution of pertechnetate ion to [[bis(1,2-dimethylphosphino)ethane] 2 Fe(Cl) 2 ].sup.⊕ Cl.sup.⊖ and heating the mixture in the presence of a source of chloride ion and a complexing agent.
Claim 8
Dependent Claim
25 words
A method in accordance with claim 6 wherein the source of chloride ion is sodium chloride and the complexing agent is ethylene glycol-bis[β-aminoethyl ether]-N,N'-tetraacetic acid.
Claim 9
Dependent Claim
49 words
A composition comprising a complex having the formula [(L).sub.2 M(X).sub.2 ].sup.⊕ X.sup.⊖, wherein each L is the same or different lipophilic ligand, each X is the same or different monovalent anionic ligand, and M is a non-toxic trivalent metal ion other than technetium, and a source of anion X.sup.⊖.
Claim 10
Dependent Claim
49 words
A composition comprising a complex having the formula [(L).sub.2 M(X).sub.2 ].sup.⊕ X.sup.⊖, wherein each L is the same or different lipophilic ligand, each X is the same or different monovalent anionic ligand, and M is a non-toxic trivalent metal ion other than technetium, and a source of anion X.sup.⊖.
Claim 11
Dependent Claim
11 words
A composition in accordance with claim 8 wherein M is iron.
Claim 12
Dependent Claim
12 words
A composition in accordance with claim 8 wherein each L is bis(1,2-dimethylphosphino)ethane.
Claim 13
Dependent Claim
13 words
A composition in accordance with claim 8 wherein each L is o-phenylene bis(dimethylarsine).
Claim 14
Dependent Claim
17 words
A composition in accordance with claim 8 wherein the source of anion X.sup.⊖ is a chloride salt.
Claim 15
Dependent Claim
12 words
A composition in accordance with claim 8 additionally containing a complexing agent.
Claim 16
Dependent Claim
20 words
A composition in accordance with claim 8 comprising [[bis(1,2-dimethylphosphino)ethane] 2 Fe(Cl) 2 ].sup.⊕ Cl.sup.⊖ and a source of chloride ion.
Claim 17
Dependent Claim
14 words
A composition in accordance with claim 8 additionally comprising one, or more, alkyl paraben.
Claim 18
Dependent Claim
14 words
A composition in accordance with claim 8 additionally comprising a calcium or magnesium salt.
Claim 19
Dependent Claim
11 words
A composition in accordance with claim 8 additionally comprising calcium chloride.
Claim 20
Dependent Claim
13 words
A composition in accordance with claim 14 additionally containing ethylene glycol-bis[β-aminoethyl ether]-N,N'-tetraacetic acid.
Claim 21
Dependent Claim
16 words
A composition in accordance with claim 14 wherein the source of chloride ion is sodium chloride.
Claim 22
Dependent Claim
6 words
[[bis(1,2-dimethylphosphino)ethane] 2 Fe(Cl) 2 ].sup.⊕ Cl.sup.⊖.
Claim 23
Dependent Claim
6 words
[[bis(1,2-dimethylphosphino)ethane] 2 Fe(Cl) 2 ].sup.⊕ Cl.sup.⊖.
References Cited (Backward Citations)
US4374821A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-05 | 1987-06-06 | 1987-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-05 | 1991-06-06 | 1991-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-05 | 1995-06-06 | 1995-12-06 | $7700.00 | Window Closed / Lapsed |