Organo-mercurial materials

Claim 1

A composition of matter comprising a metal having affinity for compounds having sulfhydryl groups, said metal being coupled covalently to an inorganic carrier having available hydroxide or oxide groups, said metal being coupled to the inorganic carrier by means of a coupling agent having a silicon portion attached to the inorganic carrier and an organic portion covalently attached to said metal, said composition of matter having the following structure: G-Si(R.sup.2).sub.3-n (R.sup.1 Y.sup.1 HgZ).sub.n where G is the inorganic carrier, R 1 is alkyl, R 2 is lower alkoxy or halo, Z is alkyl or the conjugate base of an acid, n is an integer from 1-3, and Y 1 HgZ is the residue from the reaction of a substituent having the formula -R.sup.1 Y with a compound having the formula: ZHgZ' where Y is selected from the group of hydroxyl, amino, substituted or unsubstituted acryloxy, isothiocyano, sulfhydryl or a diazonium salt, and Z' is alkyl, or the conjugate base of an acid, and where there are more than one Z, Y 1 , R 1 or R 2 , each may be the same or may be different.

Claim 10

A method of separating a sulfhydryl compound containing at least one sulfhydryl group from other compounds, comprising contacting a mixture of the sulfhydryl compound and the other compounds with an affinity product in a chromatographic column, said affinity product comprising a metal having an affinity for sulfhydryl groups, said metal being coupled covalently to an inorganic carrier having available hydroxide or oxide groups, said metal being coupled to the inorganic carrier by means of a silane coupling agent having the formula: (YR.sup.1).sub.n Si(R.sup.2).sub.4-n where Y is a functional group which will react with a mercuric compound, selected from hydroxyl, amino, carboxyllic acid, acyl, acyloxy, isocyano, isothiocyano, sulfhydryl or a diazonium salt; R 1 is alkyl, lower alkenyl, lower alkyl-aryl, or aryl; R 2 is selected from the group of lower alkoxy, phenoxy and halo; and n is an integer from 1 to 3, and separating such mixture from an affinity product.

Claim 11

A method of separating a sulfhydryl compound containing at least one sulfhydryl group from other compounds, comprising contacting a mixture of the sulfhydryl compound and the other compounds with an affinity product in a chromatographic column, said affinity product comprising a metal having an affinity for sulfhydryl groups, said metal being coupled covalently to an inorganic carrier having available hydroxide or oxide groups, said metal being coupled to the inorganic carrier by means of a silane coupling agent having the formula: (YR.sup.1).sub.n Si(R.sup.2).sub.4-n where Y is a functional group which will react with a mercuric compound, selected from hydroxyl, amino, carboxyllic acid, acyl, acyloxy, isocyano, isothiocyano, sulfhydryl or a diazonium salt; R 1 is alkyl, lower alkenyl, lower alkyl-aryl, or aryl; R 2 is selected from the group of lower alkoxy, phenoxy and halo; and n is an integer from 1 to 3, and separating such mixture from an affinity product.