Patent US4439413A successfully refreshed from Google Patents.
US4439413A
Expired / Lapsed
US
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Radioactive diagnostic agent for bone scanning and non-radioactive carrier therefor
Assignee: NILHON MEDI-PHYSICS Co Ltd
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Filing: 1981-09-11
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Granted: 1984-03-27
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Expires: 2001-09-11
Abstract
Abstract A radioactive diagnostic agent for bone scanning, which comprises 99mTc and a non-radioactive carrier comprising (A) at least one chosen from methanehydroxydiphosphonic acid and their salts and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1 and prevents the accumulation of radioactivity in liver so that definite diagnosis can be assured.
Inventors
- 👤 Miki Hayashi
- 👤 Keietsu Takahashi
- 👤 Masaaki Hazue
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 09:25
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K2123/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
34 words
A non-radioactive carrier, which comprises (A) methanehydroxydiphosphonic acid or a pharmaceutically acceptable water soluble salt thereof and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1.
Claim 2
Dependent Claim
34 words
A non-radioactive carrier, which comprises (A) methanehydroxydiphosphonic acid or a pharmaceutically acceptable water soluble salt thereof and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1.
Claim 3
Dependent Claim
22 words
The carrier according to claim 1, wherein the weight ratio of the components (A) and (B) is from about 1:1 to 3:1.
Claim 4
Dependent Claim
15 words
The carrier according to claim 1, wherein the components (A) and (B) are both water-soluble.
Claim 5
Dependent Claim
14 words
The carrier according to claim 1, wherein the component (B) is a stannous salt.
Claim 6
Dependent Claim
18 words
The carrier according to claim 1, wherein the components (A) and (B) are dissolved in an aqueous medium.
Claim 7
Dependent Claim
13 words
The carrier according to claim 1, which is in a lyopholized powder state.
Claim 8
Dependent Claim
15 words
The carrier according to claim 1, which further comprises (C) a pharmaceutically acceptable reductive stabilizer.
Claim 9
Dependent Claim
27 words
The carrier according to claim 7, wherein the component (C) is the one chosen from ascorbic acid, erythorbic acid and gentisic acid, and their salts or esters.
Claim 10
Dependent Claim
22 words
The carrier according to claim 7, wherein the weight proportion of the components (A) and (C) is from about 1:1 to 20:1.
Claim 11
Dependent Claim
46 words
A radioactive diagnostic agent for bone scanning which comprises 99m Tc and a non-radioactive carrier which comprises (A) methanehydroxydiphosphonic acid or a pharmaceutically acceptable water soluble salt thereof and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1.
Claim 12
Dependent Claim
46 words
A radioactive diagnostic agent for bone scanning which comprises 99m Tc and a non-radioactive carrier which comprises (A) methanehydroxydiphosphonic acid or a pharmaceutically acceptable water soluble salt thereof and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1.
Claim 13
Dependent Claim
51 words
A radioactive diagnostic agent for bone scanning which comprises 99m Tc in the form of pertechnetate and a non-radioactive carrier which comprises (A) methanehydroxydiphosphonic acid or a pharmaceutically acceptable water soluble salt thereof and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1.
Claim 14
Dependent Claim
51 words
A radioactive diagnostic agent for bone scanning which comprises 99m Tc in the form of pertechnetate and a non-radioactive carrier which comprises (A) methanehydroxydiphosphonic acid or a pharmaceutically acceptable water soluble salt thereof and (B) at least one reducing agent for pertechnetates in a weight ratio of about 1:1 to 7:1.
Claim 15
Dependent Claim
24 words
The diagnostic agent as in claim 10 or 11 wherein the weight ratio of components (A) and (B) is from about 1:1 to 3:1.
Claim 16
Dependent Claim
16 words
The diagnostic agent as in claim 10 or 11 wherein component (B) is a stannous salt.
Claim 17
Dependent Claim
21 words
The diagnostic agent as in claim 10 or 13 wherein the components (A) and (B) are dissolved in an aqueous medium.
Claim 18
Dependent Claim
16 words
The diagnostic agent as in claim 10 or 13 which is in a lyophilized powder form.
Claim 19
Dependent Claim
18 words
The diagnostic agent as in claim 10 or 11 which further comprises (C) a pharmaceutically acceptable reductive stabilizer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-27 | 1987-09-26 | 1988-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-27 | 1991-09-26 | 1992-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-27 | 1995-09-26 | 1996-03-27 | $7700.00 | Window Closed / Lapsed |