US4443447A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenyl-substituted tricyclic antibacterial agents
Assignee: Riker Laboratories Inc
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Filing: 1982-10-25
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Granted: 1984-04-17
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Expires: 2002-10-25
Abstract
Abstract Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein X is selected from the group consisting of --O--, --CH 2 and ##STR2## m is 0 or 1; R 1 is selected from the group consisting of hydrogen, nitro, amino, lower alkyl, lower alkanamido, lower N,N-dialkylamino, formamido, hydroxy, lower alkoxy, halogen, lower haloalkanamido and pyrryl; n is 1 or 2; and R 2 is selected from the group consisting of hydrogen, methyl, fluoro, chloro and nitro. Acyl chlorides, esters, alkylaminoalkyl ester salts, amides and pharmaceutically acceptable carboxylate salts are also disclosed. Pharmaceutical compositions containing these compounds, methods of using these compound and synthetic intermediates are also disclosed.
Inventors
- 👤 John F. Gerster
- 👤 Richard M. Stern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 00:20
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/32; C07D207/325; A; A61; A61P; A61P31/00; A61P31/04; C07C; C07C205/00; C07C205/27; C07C205/35; C07C205/36; C07C205/37; C07D215/00; C07D215/02; C07D215/04; C07D215/06; C07D215/16; C07D215/20; C07D241/00; C07D241/36; C07D241/38; C07D241/40; C07D241/42; C07D265/00; C07D265/28; C07D265/34; C07D265/36; C07D455/00; C07D455/03; C07D455/04; C07D471/00; C07D471/02; C07D471/06
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
98 words
A compound of the formula ##STR87## wherein X is selected from the group consisting of a --O--, --CH 2 -- and ##STR88## m is 0 or 1; R 1 is selected from the group consisting of hydrogen, nitro, amino, lower alkyl, lower alkanamido, lower N,N-dialkylamino, formamido, hydroxy, alkoxy, halogen, lower haloalkanamido and pyrryl; n is 1 or 2; and R 2 is selected from the group consisting of hydrogen, methyl, fluoro, chloro and nitro; or a derivative thereof selected from the group consisting of an acyl chloride, ester, alkylaminoalkyl ester salt, amido, and a pharmaceutically acceptable carboxylate salt.
Claim 2
Dependent Claim
98 words
A compound of the formula ##STR87## wherein X is selected from the group consisting of a --O--, --CH 2 -- and ##STR88## m is 0 or 1; R 1 is selected from the group consisting of hydrogen, nitro, amino, lower alkyl, lower alkanamido, lower N,N-dialkylamino, formamido, hydroxy, alkoxy, halogen, lower haloalkanamido and pyrryl; n is 1 or 2; and R 2 is selected from the group consisting of hydrogen, methyl, fluoro, chloro and nitro; or a derivative thereof selected from the group consisting of an acyl chloride, ester, alkylaminoalkyl ester salt, amido, and a pharmaceutically acceptable carboxylate salt.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein X is --O--.
Claim 4
Dependent Claim
12 words
A compound according to claim 1, wherein X is --CH 2 --.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, wherein X is ##STR89##
Claim 6
Dependent Claim
10 words
A compound according to claim 1, wherein m is 0.
Claim 7
Dependent Claim
11 words
A compound according to claim 3, wherein R 2 is hydrogen.
Claim 8
Dependent Claim
12 words
The compound 2,3-dihydro-3-methyl-7-oxo-10-phenyl-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid or a derivative thereof according to claim 1.
Claim 9
Dependent Claim
12 words
The compound 6,7-dihydro-5-methyl-1-oxo-8-phenyl-1H,5H-benzo[ij]quinolizine-2-carboxylic acid or a derivative thereof according to claim 1.
Claim 10
Dependent Claim
12 words
The compound 6,7-dihydro-8-(4-methoxyphenyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid or a derivative thereof according to claim 1.
Claim 11
Dependent Claim
23 words
A method of inhibiting the growth of microorganisms, comprising contacting said microorganisms with an effective amount of a compound according to claim 1.
Claim 12
Dependent Claim
19 words
A pharmaceutical composition comprising an effective amount of a compound according to claim 1 and a pharmaceutically acceptable vehicle.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-17 | 1987-10-17 | 1988-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-17 | 1991-10-17 | 1992-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-17 | 1995-10-17 | 1996-04-17 | $7700.00 | Window Closed / Lapsed |