US4459298A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of suppressing appetite
Assignee: Novartis Corp
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Filing: 1982-09-28
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Granted: 1984-07-10
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Expires: 2002-09-28
Abstract
Abstract Certain pyrazolo[4,3-c]quinolin-3-ones, e.g. those of the formula ##STR1## wherein R 1 is hydrogen, alkyl or alkoxy with up to 4 carbon atoms each, hydroxy, fluoro, chloro, bromo or trifluoromethyl; and R is phenyl, fluorophenyl or pyridyl; or pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising above compounds are useful for suppressing appetite in mammals.
Inventors
- 👤 Patrick S. Bernard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:26
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
78 words
A method of suppressing appetite in mammals comprising the enteral or parenteral administration of an appetite-suppressant effective amount of a compound of the formula ##STR3## or a tautomer thereof wherein R 1 is hydrogen, alkyl or alkoxy with up to 4 carbon atoms each, hydroxy, fluoro, chloro, bromo or trifluoromethyl; and R is phenyl, fluorophenyl, or pyridyl; or a pharmaceutically acceptable salt thereof; or of a pharmaceutical composition comprising a said compound in combination with a pharmaceutical carrier.
Claim 2
Independent Claim
78 words
A method of suppressing appetite in mammals comprising the enteral or parenteral administration of an appetite-suppressant effective amount of a compound of the formula ##STR3## or a tautomer thereof wherein R 1 is hydrogen, alkyl or alkoxy with up to 4 carbon atoms each, hydroxy, fluoro, chloro, bromo or trifluoromethyl; and R is phenyl, fluorophenyl, or pyridyl; or a pharmaceutically acceptable salt thereof; or of a pharmaceutical composition comprising a said compound in combination with a pharmaceutical carrier.
Claim 3
Dependent Claim
19 words
A method according to claim 1 comprising the enteral administration of a pharmaceutical composition as defined in claim 1.
Claim 4
Dependent Claim
30 words
A method according to claim 2 wherein R 1 is hydrogen; or R 1 is 7- or 8-(methyl, methoxy, chloro, fluoro or trifluoromethyl); and R is phenyl, fluorophenyl or 3-pyridyl.
Claim 5
Dependent Claim
31 words
A method according to claim 2 wherein R 1 is hydrogen or 8-fluoro; and R is phenyl or p-fluorophenyl; and the pharmaceutically acceptable salt is the sodium, hydrochloride or mesylate salt.
Claim 6
Dependent Claim
23 words
A method of suppressing appetite according to claim 2 wherein the appetite-suppressant compound is 2-phenylpyrazolo-[4,3-c]-quinolin-3(5H)-one; or the sodium, hydrochloride or mesylate salt thereof.
Claim 7
Dependent Claim
23 words
A method of suppressing appetite according to claim 2 wherein the appetite-suppressant compound is 2-(p-fluorophenyl)-8-fluoropyrazolo[4,3-c]quinolin-3-(5H)-one or the sodium, hydrochloride or mesylate salt thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-10 | 1988-01-09 | 1988-07-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-10 | 1992-01-09 | 1992-07-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-10 | 1996-01-09 | 1996-07-10 | $7700.00 | Window Closed / Lapsed |