Patent US4472372A successfully refreshed from Google Patents.
US4472372A
Expired / Lapsed
US
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Polymeric diffusion matrix containing chlorpheniramine maleate
Assignee: Key Pharmaceuticals Inc
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Filing: 1982-09-28
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Granted: 1984-09-18
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Expires: 2002-09-28
Abstract
Abstract There is disclosed a polymeric diffusion matrix for the sustained release of chlorpheniramine maleate by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of chlorpheniramine maleate.
Inventors
- 👤 Alec D. Keith
- 👤 Wallace Snipes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:01
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K31/00; A61K31/13; A61K31/135; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/56; A61K31/565
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
113 words
In a method for the administration of chlorpheniramine maleate to a patient to provide said patient with an antihistamine effect, the improvement comprising applying to the skin of said patient a self-supporting diffusion matrix made by casting or molding and comprising from about 2 to about 60% by weight of a polar plasticizer, from about 6 to about 20% by weight of polyvinylalcohol molecular weight of about 50,000 to about 150,000, from about 2 to about 10% by weight polyvinylpyrrolidone molecular weight of from about 15,000 to about 85,000, and a pharmaceutically effective amount of chlorpheniramine maleate to transdermally deliver and provide a sustained release of said chlorpheniramine maleate over a prolonged period.
Claim 2
Dependent Claim
113 words
In a method for the administration of chlorpheniramine maleate to a patient to provide said patient with an antihistamine effect, the improvement comprising applying to the skin of said patient a self-supporting diffusion matrix made by casting or molding and comprising from about 2 to about 60% by weight of a polar plasticizer, from about 6 to about 20% by weight of polyvinylalcohol molecular weight of about 50,000 to about 150,000, from about 2 to about 10% by weight polyvinylpyrrolidone molecular weight of from about 15,000 to about 85,000, and a pharmaceutically effective amount of chlorpheniramine maleate to transdermally deliver and provide a sustained release of said chlorpheniramine maleate over a prolonged period.
Claim 3
Dependent Claim
27 words
The method of claim 1 wherein said chlorpheniramine maleate is present in an amount to provide sustained release of about 1 to about 30 mg per day.
Claim 4
Dependent Claim
13 words
The polymeric diffusion matrix of claim 1 wherein said polar plasticizer is glycerol.
Claim 5
Dependent Claim
20 words
The polymeric diffusion matrix of claim 1 wherein said polyvinylpyrrolidone has a molecular weight of about 20,000 to about 60,000.
References Cited (Backward Citations)
GB1465665A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-18 | 1988-03-19 | 1988-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-18 | 1992-03-19 | 1992-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-18 | 1996-03-19 | 1996-09-18 | $7700.00 | Window Closed / Lapsed |