Patent US3560093A successfully refreshed from Google Patents.
Patent US4473568A successfully refreshed from Google Patents.
US4473568A
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Antibacterial thiazolidine or thiomorpholine substituted quinolines
Assignee: Warner Lambert Co LLC
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Filing: 1983-03-01
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Granted: 1984-09-25
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Expires: 2003-03-01
Abstract
Abstract Certain thiazolidine or thiomorpholine substituted quinoline and pyridobenzoxazine compounds are antibacterial agents. Method for their preparation and use are disclosed.
Inventors
- 👤 Marland P. Hutt, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 09:46
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56; C07D417/00; C07D417/02; C07D417/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
91 words
A compound having the structural formula Ia ##STR10## wherein Y and Y 1 are independently hydrogen, fluorine, chlorine, or bromine; n is 0 or the integer 1 or 2; R 1 is hydrogen, alkyl having from one to six carbon atoms or a cation derived from a pharmaceutically acceptable metal or amine; R 2 is alkyl having from one to four carbon atoms, vinyl or haloalkyl having from two to four carbon atoms; R 3 is hydrogen, methyl, or ethyl; ##STR11## is thiazolidine or thiomorpholine; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
91 words
A compound having the structural formula Ia ##STR10## wherein Y and Y 1 are independently hydrogen, fluorine, chlorine, or bromine; n is 0 or the integer 1 or 2; R 1 is hydrogen, alkyl having from one to six carbon atoms or a cation derived from a pharmaceutically acceptable metal or amine; R 2 is alkyl having from one to four carbon atoms, vinyl or haloalkyl having from two to four carbon atoms; R 3 is hydrogen, methyl, or ethyl; ##STR11## is thiazolidine or thiomorpholine; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
29 words
A compound defined in claim 1 wherein Y is fluorine; Y' is hydrogen or fluorine; R 2 is ethyl; R 3 is methyl, and the pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
17 words
The compound defined in claim 1 having the name 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-thiazolidinyl)-3-quinolinecarboxylic acid and the pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
17 words
The compound defined in claim 1 having the name 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-thiomorpholinyl)-3-quinolinecarboxylic acid and the pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
18 words
The compound defined in claim 1 having the name 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-thiomorpholinyl)-3-quinolinecarboxylic acid, S-oxide and the pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
18 words
The compound defined in claim 1 having the name 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-thiomorpholinyl)-3-quinolinecarboxylic acid, S,S-dioxide and the pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
17 words
The compound defined in claim 1 having the name 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-thiazolidinyl)-3-quinolinecarboxylic acid and the pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
17 words
The compound defined in claim 1 having the name 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(4-thiomorpholinyl)-3-quinolinecarboxylic acid and the pharmaceutically acceptable salts thereof.
Claim 10
Dependent Claim
24 words
A pharmaceutical composition which comprises an antibacterially effective amount of a compound as defined in claim 1, in combination with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
30 words
A method for treating bacterial infections in a mammal which comprises administering an antibacterial effective amount of the pharmaceutical composition defined in claim 9 to a mammal in need thereof.
References Cited (Backward Citations)
US4292317A
Cited
US4382892A
Cited
US4399134A
Cited
US4398029A
Cited
US4398029B1
Cited
JPS57149286A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-25 | 1988-03-26 | 1988-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-25 | 1992-03-26 | 1992-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-25 | 1996-03-26 | 1996-09-25 | $7700.00 | Window Closed / Lapsed |