Patent US4481189A successfully refreshed from Google Patents.
US4481189A
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Process for preparing sterilized plasma and plasma derivatives
Assignee: New York Blood Center
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Filing: 1982-04-14
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Granted: 1984-11-06
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Expires: 2002-04-14
Abstract
Abstract A mammalian blood plasma or plasma derivative substantially free of active hepatitis B or non-A, non-B viruses is disclosed, the plasma being characterized by the presence of factor VIII, the percent by weight of denatured factor VIII to the sum of undenatured factor VIII and denatured factor VIII being less than 50%. The plasma is sterilized by contact with a detergent, alcohol or ether, preferably a mixture of detergent and ether, usually followed by removal of the viral sterilizing agent.
Inventors
- 👤 Alfred M. Prince
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:53
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/081; A61K; A61K31/00; A61K31/13; A61K31/14; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61L2/16; A61L2/18; A61P; A61P7/00; A61P7/04; C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
36 words
A process for inactivating the hepatitis B virus in mammalian blood plasma or a concentrate therefrom which comprises contacting said blood plasma or a concentrate therefrom with ether for a time sufficient to inactivate said virus.
Claim 2
Dependent Claim
36 words
A process for inactivating the hepatitis B virus in mammalian blood plasma or a concentrate therefrom which comprises contacting said blood plasma or a concentrate therefrom with ether for a time sufficient to inactivate said virus.
Claim 3
Dependent Claim
16 words
A process according to claim 1, wherein said plasma is contacted additionally with a nonionic detergent.
Claim 4
Dependent Claim
44 words
A process according to claim 1, wherein said ether has the formula R.sup.1 --O--R.sup.2 wherein R 1 and R 2 are independently C 1 to C 18 alkyl or alkenyl which alkyl or alkenyl can contain an oxygen or sulphur atom in the chain.
Claim 5
Dependent Claim
20 words
A process according to claim 1, wherein the plasma is contacted with a mixture of nonionic detergent and an ether.
Claim 6
Dependent Claim
18 words
A process according to claim 2, wherein said contact with nonionic detergent and ether is a successive contact.
Claim 7
Dependent Claim
38 words
A process according to claim 1, wherein said plasma remains in contact with said ether for a period of time of at least one minute and is maintained at a temperature of between -5° C. and 50° C.
Claim 8
Dependent Claim
20 words
A process according to claim 6, wherein the ether is present in an amount of at least 0.1% by weight.
Claim 9
Dependent Claim
28 words
A process according to claim 7, wherein said ether is present in an amount of between 0.1 and 50% by weight based upon the weight of the plasma.
Claim 10
Dependent Claim
14 words
A process according to claim 8, wherein following said treatment said ether is removed.
Claim 11
Dependent Claim
18 words
A process according to claim 1, wherein said mammalian blood plasma is human blood plasma or plasma derivative.
Claim 12
Dependent Claim
23 words
A process according to claim 10, wherein said human blood plasma is pooled blood plasma or plasma derivative from such human plasma pools.
Claim 13
Dependent Claim
19 words
A process according to claim 1, wherein the blood plasma subjected to said process contains Non-A, Non-B Hepatitis virus.
Claim 14
Dependent Claim
16 words
A process according to claim 1, wherein a concentrate of Factor VIII is treated with ether.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-06 | 1988-05-07 | 1988-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-06 | 1992-05-07 | 1992-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-06 | 1996-05-07 | 1996-11-06 | $7700.00 | Window Closed / Lapsed |