Patent US4481191A successfully refreshed from Google Patents.
US4481191A
Expired / Lapsed
US
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Method for controlling blood pressure
Assignee: University of California
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Filing: 1983-03-30
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Granted: 1984-11-06
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Expires: 2003-03-30
Abstract
Abstract A method is provided for treating high blood pressure and disturbances of cardiac function by administering a therapeutically effective dosage of dynorphin-related opioid peptides, such as dynorphin(1-13) and dynorphin(1-10) amide, having at least ten amino acids linked sequentially by peptide bonds and with the five amino acids from the N-terminal end being the same as, or mimicking, Leu-enkephalin. Administration may be over a period of time, as for individuals with chronic high blood pressure, and may be by dispensing the medicament in aerosol form.
Inventors
- 👤 Edward T. Wei
- 👤 Nancy M. Lee
- 👤 Jaw-Kang Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:58
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; A; A61; A61P; A61P9/00; A61P9/06; A61P9/12; A61K; A61K38/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
22 words
A method for treating high blood pressure or disturbances of cardiac function comprising: administering a therapeutically effective amount of dynorphin(1-13) or dynorphin(1-10).
Claim 2
Independent Claim
22 words
A method for treating high blood pressure or disturbances of cardiac function comprising: administering a therapeutically effective amount of dynorphin(1-13) or dynorphin(1-10).
Claim 3
Dependent Claim
10 words
The method as in claim 1 wherein dynorphin(1-10) is amidated.
Claim 4
Dependent Claim
30 words
The method as in claim 1 or 2 wherein the administering is at a daily dosage rate of from about 0.14 to about 0.43 mg per kg of body weight.
Claim 5
Dependent Claim
26 words
The method as in claim 1 or 2 wherein the administering is at a dosage of at least about 0.70 mg per kg of body weight.
Claim 6
Dependent Claim
17 words
The method as in claim 1 or 2 wherein the administering is oral, intranasal, or by injection.
Claim 7
Dependent Claim
24 words
The method as in claim 3 wherein the administering is by means of inhalation, and the dynorphin(1-13) or dynorphin(1-10) is in an aerosolized form.
Claim 8
Dependent Claim
23 words
The method as in claim 1 or 2 wherein the therapeutically effective dosage lowers such individual's blood pressure by at least about 10%.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-06 | 1988-05-07 | 1988-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-06 | 1992-05-07 | 1992-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-06 | 1996-05-07 | 1996-11-06 | $7700.00 | Window Closed / Lapsed |