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US4489089A
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Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
Assignee: Wyeth Holdings LLC
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Filing: 1984-01-13
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Granted: 1984-12-18
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Expires: 2004-01-13
Abstract
Abstract This disclosure describes novel N-[ω-(1H-imidazol-1-yl)alkyl]amides which possess the property of inhibiting the enzyme thromboxane synthetase.
Inventors
- 👤 William B. Wright, Jr.
- 👤 Jeffrey B. Press
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 21:33
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08; C07D405/00; C07D405/02; C07D405/12
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
123 words
A compound selected from the group consisting of those of the formula: ##STR8## wherein A is a divalent moiety of the formulae: --C.sub.n H.sub.2n -- or --CH.sub.2 CH═CHCH.sub.2 -- wherein n is an integer from 2 to 8, inclusive; R 1 is hydrogen, alkyl (C 1 -C 3 ) or benzyl; R 2 and R 3 are each hydrogen, alkyl(C 1 -C 3 ) or phenyl, Q is a divalent moiety of the formulae: ##STR9## wherein m is zero, 1, 2 or 3; and HET is a heterocyclic moiety of the formulae: ##STR10## wherein Y is oxo or thio; R 4 is hydrogen, halogen, dihalogen, lower alkyl or nitro; and R 5 is hydrogen or halogen; and the pharmacologically acceptable acid-addition salts thereof.
Claim 2
Dependent Claim
123 words
A compound selected from the group consisting of those of the formula: ##STR8## wherein A is a divalent moiety of the formulae: --C.sub.n H.sub.2n -- or --CH.sub.2 CH═CHCH.sub.2 -- wherein n is an integer from 2 to 8, inclusive; R 1 is hydrogen, alkyl (C 1 -C 3 ) or benzyl; R 2 and R 3 are each hydrogen, alkyl(C 1 -C 3 ) or phenyl, Q is a divalent moiety of the formulae: ##STR9## wherein m is zero, 1, 2 or 3; and HET is a heterocyclic moiety of the formulae: ##STR10## wherein Y is oxo or thio; R 4 is hydrogen, halogen, dihalogen, lower alkyl or nitro; and R 5 is hydrogen or halogen; and the pharmacologically acceptable acid-addition salts thereof.
Claim 3
Dependent Claim
7 words
The compound according to claim 1; N-[3-(1H-imidazol-1-yl)propyl]-2-furanecarboxamide.
Claim 4
Dependent Claim
7 words
The compound according to claim 1; 5-chloro-N-[4-(1H-imidazol-1-yl)butyl]-2-thiophenecarboxamide.
Claim 5
Dependent Claim
7 words
The compound according to claim 1; N-[3-(1H-imidazol-1yl)propyl]-5-nitro-2-furanecarboxamide.
Claim 6
Dependent Claim
8 words
The compound according to claim 1; N-[3-(1H-imidazol-1-yl)propyl]-α-oxo-thiophene acetamide.
Claim 7
Dependent Claim
7 words
The compound according to claim 1; 3-chloro-N-[2-(1H-imidazol-1-yl)ethyl]-2-benzo[b]thiophenecarboxamide.
Claim 8
Dependent Claim
7 words
The compound according to claim 1; N-[4-(1H-imidazol-1-yl)butyl]-2-thiophenecarboxamide.
Claim 9
Dependent Claim
7 words
The compound according to claim 1; 5-chloro-N-[3-(1H-imidazol-1-yl)propyl]-2-thiophenecarboxamide.
Claim 10
Dependent Claim
7 words
The compound according to claim 1; 3-chloro-N-[3-(1H-imidazol-1-yl)propyl]-2-benzo[b]thiophenecarboxamide.
Claim 11
Dependent Claim
7 words
The compound according to claim 1; 4,5-dibromo-N-[3-(1H-imidazol-1-yl)propyl]-2-thiophenecarboxamide.
Claim 12
Dependent Claim
7 words
The compound according to claim 1; 5-chloro-N-[3-(1H-imidazol-1-yl)propyl]-2-benzo[b]thiophenecarboxamide.
Claim 13
Dependent Claim
30 words
The method of inhibiting thromboxane synthetase enzyme in a mammal which comprises administering internally to said mammal an effective thromboxane synthetase enzyme inhibiting amount of a compound of claim 1.
Claim 14
Dependent Claim
33 words
A thromboxane synthetase enzyme inhibiting composition of matter in dosage unit form comprising from about 10 mg. to about 700 mg. of a compound of claim 1 in association with a pharmaceutical carrier.
References Cited (Backward Citations)
US3646057A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-18 | 1988-06-18 | 1988-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-18 | 1992-06-18 | 1992-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-18 | 1996-06-18 | 1996-12-18 | $7700.00 | Window Closed / Lapsed |