US4489096A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Quinone compounds, their production and use
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1983-07-05
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Granted: 1984-12-18
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Expires: 2003-07-05
Abstract
Abstract New quinone compounds of the formula: ##STR1## wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di- alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or their hydroquinone-form compounds, or pharmaceutically acceptable salts thereof, have useful physiological activities such as antiasthmatic and antiallergic activities.
Inventors
- 👤 Shinji Terao
- 👤 Yoshitaka Maki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:16
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; A; A61; A61P; A61P3/00; A61P3/06; C07C; C07C46/00; C07C50/00; C07C50/38; C07C66/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
51 words
A compound of the formula: ##STR12## wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or dialkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
51 words
A compound of the formula: ##STR12## wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or dialkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
15 words
A compound as claimed in claim 1, wherein the compound is in the quinone form.
Claim 4
Dependent Claim
11 words
A compound as claimed in claim 1, wherein Y is carboxyl.
Claim 5
Dependent Claim
11 words
A compound as claimed in claim 1, wherein Y is carbamoyloxymethyl.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1, wherein the compound is 2,3,5-trimethyl-6-(11-carboxyundeca-5,10-diynyl)-1,4-benzoquinone.
Claim 7
Dependent Claim
12 words
A compound as claimed in claim 1, wherein the compound is 2,3-dimethoxy-5-methyl-6-(11-carboxyundeca-5,10-diynyl)-1,4-benzoquinone.
Claim 8
Dependent Claim
12 words
A compound as claimed in claim 1, wherein the compound is 2-(12-carbamoyloxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone.
Claim 9
Dependent Claim
12 words
A compound as claimed in claim 1, wherein the compound is 2-(12-carbamoyloxydodeca-5,10-diynyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone.
Claim 10
Dependent Claim
81 words
A pharmaceutical composition suitable for suppressing the generation and release of SRS-A, which comprises as an active ingredient, an effective amount of a compound of the formula: ##STR13## wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or dialkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient therefor.
Claim 11
Dependent Claim
81 words
A pharmaceutical composition suitable for suppressing the generation and release of SRS-A, which comprises as an active ingredient, an effective amount of a compound of the formula: ##STR13## wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or dialkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient therefor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-18 | 1988-06-18 | 1988-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-18 | 1992-06-18 | 1992-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-18 | 1996-06-18 | 1996-12-18 | $7700.00 | Window Closed / Lapsed |