US4492696A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperazine and homopiperazine compounds
Assignee: Institut Servier de Medecine Translationnelle SARL
•
Filing: 1983-02-15
•
Granted: 1985-01-08
•
Expires: 2003-02-15
Abstract
Abstract Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C 3 to C 5 , in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH; B is CH or a nitrogen atom; m is 2 or 3; X--Y-- represents --CH═CH-- (CR'R") n -- in which n is zero or 1, and R' and R" are hydrogen or methyl; Z is oxygen or sulfur, R is hydrogen, alkyl from C 1 to C 5 , cycloalkyl from C 3 to C 7 , or phenyl optionally substituted by fluorine, chlorine or alkyl from C 1 to C 5 , and T is hydrogen, fluorine, chlorine or alkyl from C 1 to C 5 . These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxy.
Inventors
- 👤 Gilbert Reginier
- 👤 Michel Laubie
- 👤 Jacques Duhault
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:13
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/12; A; A61; A61P; A61P9/00; C07D409/00; C07D409/02; C07D409/12
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
224 words
A compound selected from the group consisting of: piperazine and homopiperazine compounds of the formula: ##STR16## in which: A is selected from the group consisting of hydrocarbon radicals having from 3 to 5 carbon atoms inclusive, in straight and branched chain and these radicals containing one and two double bonds and substituted by one and two hydroxy; m is an integer selected from 2 and 3; --X--Y -- represents a group of the formula: --CH═CH--(CR'R") n -- in which n is selected from the group consisting of 0 and 1, and R' and R" which are the same or different are each selected from the group consisting of hydrogen and methyl; Z is selected from the group consisting of oxygen and sulfur; R is selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms inclusive, cycloalkyl having from 3 to 7 carbon atoms inclusive, unsubstituted phenyl and phenyl mono- and poly-substituted by a substituent selected from the group consisting of fluorine, chlorine and alkyl having from 1 to 5 carbon atoms inclusive; T is selected from the group consisting of hydrogen, fluorine, chlorine and alkyl having from 1 to 5 carbon atoms inclusive, and the group ##STR17## is bonded to either one of the cycles forming the group: ##STR18## in the formula I; and physiologically tolerable addition salts thereof.
Claim 2
Dependent Claim
224 words
A compound selected from the group consisting of: piperazine and homopiperazine compounds of the formula: ##STR16## in which: A is selected from the group consisting of hydrocarbon radicals having from 3 to 5 carbon atoms inclusive, in straight and branched chain and these radicals containing one and two double bonds and substituted by one and two hydroxy; m is an integer selected from 2 and 3; --X--Y -- represents a group of the formula: --CH═CH--(CR'R") n -- in which n is selected from the group consisting of 0 and 1, and R' and R" which are the same or different are each selected from the group consisting of hydrogen and methyl; Z is selected from the group consisting of oxygen and sulfur; R is selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms inclusive, cycloalkyl having from 3 to 7 carbon atoms inclusive, unsubstituted phenyl and phenyl mono- and poly-substituted by a substituent selected from the group consisting of fluorine, chlorine and alkyl having from 1 to 5 carbon atoms inclusive; T is selected from the group consisting of hydrogen, fluorine, chlorine and alkyl having from 1 to 5 carbon atoms inclusive, and the group ##STR17## is bonded to either one of the cycles forming the group: ##STR18## in the formula I; and physiologically tolerable addition salts thereof.
Claim 3
Dependent Claim
11 words
A compound of claim 1 which is 1-(4,6-bis allylamino s.triazin-2-yl)-4-(benzothien-5-yl methyl)piperazine.
Claim 4
Dependent Claim
33 words
A pharmaceutical composition, suitable for use in the treatment of hypoxia, containing as active ingredient a compound of claim 1, in an amount effective for such purpose, together with a suitable pharmaceutical carrier.
Claim 5
Dependent Claim
41 words
A method for treating a living animal body afflicted with a tissular hypoxy, comprising the step of administering to the said living animal an amount of a compound of claim 1 which is effective for the alleviation of the said condition.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-08 | 1988-07-09 | 1989-01-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-08 | 1992-07-09 | 1993-01-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-08 | 1996-07-09 | 1997-01-08 | $7700.00 | Window Closed / Lapsed |