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US4495189A Expired / Lapsed US ⏱️ 0.0 years remaining

Condensed pyrimidines

Assignee: CHINOIN GYOGLYSZER ES VAGYESZETI TERMEKEK GYARA RT
•
Filing: 1982-04-02
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Granted: 1985-01-22
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Expires: 2002-04-02
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Abstract

Abstract New compounds of the following formula are disclosed: 1,6-dimethyl-3-carbamoyl-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)-pyrimidine; 1,6-dimethyl-3-(N-tertiary-butyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-(N-2-phenethyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-[N-(3,3-diphenyl-propyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; and 1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine, as well as pharmaceutical compositions containing these compounds and a method of inhibiting thrombocyte aggregation in mammals employing a pharmaceutically effective amount of at least one of these compounds.

Inventors

  • 👤 Zoltan Meszaros
  • 👤 Jozsef Knoll
  • 👤 Peter Szentmiklosi
  • 👤 Istvan Hermecz
  • 👤 Agnes Horvath
  • 👤 Sandor Virag
  • 👤 Lelle Vasvari
  • 👤 Agoston David

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-29 05:05
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 1 words
1,6-dimethyl-3-[N(3,3-diphenyl-propyl)carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine.
Claim 2
Dependent Claim 1 words
1,6-dimethyl-3-[N(3,3-diphenyl-propyl)carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine.
Claim 3
Independent Claim 36 words
A method of inhibiting thrombocyte aggregation which comprises the step of administering to a mammal susceptible to thrombocyte aggregation a pharmaceutically effective amount of the compound selected from the group consisting of: 1,6-dimethyl-3-carbamoyl-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2a)-pyrimidine; 1,6-dimethyl-3-(N-tertiary-butyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-(N-2-phenethyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-[N-(3,3-diphenyl-propyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine;
Claim 4
Independent Claim 36 words
A method of inhibiting thrombocyte aggregation which comprises the step of administering to a mammal susceptible to thrombocyte aggregation a pharmaceutically effective amount of the compound selected from the group consisting of: 1,6-dimethyl-3-carbamoyl-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2a)-pyrimidine; 1,6-dimethyl-3-(N-tertiary-butyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-(N-2-phenethyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-[N-(3,3-diphenyl-propyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine;
Claim 5
Dependent Claim 3 words
6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; and 1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine.
Claim 6
Dependent Claim 3 words
6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; and 1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine.

References Cited (Backward Citations)

US3585198A Cited
US3642797A Cited
US4209622A Cited
US4022897A Cited
US3960863A Cited
US4066766A Cited
US4122274A Cited
US4192944A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-01-22 1988-07-23 1989-01-22 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-01-22 1992-07-23 1993-01-22 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-01-22 1996-07-23 1997-01-22 $7700.00 Window Closed / Lapsed

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