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US4530838A
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Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals
Assignee: Salk Institute for Biological Studies
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Filing: 1983-07-08
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Granted: 1985-07-23
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Expires: 2003-07-08
Abstract
Abstract CGRP (calcitonin-gene-related peptide) has the formula: ##STR1## A related peptide has the residue Lys instead of Glu in the 35-position. CGRP or this homolog or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception.
Inventors
- 👤 Ronald M. Evans
- 👤 Larry Swanson
- 👤 Wylie W. Vale, Jr.
- 👤 Michael G. Rosenfeld
- 👤 Susan G. Amara
- 👤 Marvin R. Brown
- 👤 Jean E. F. Rivier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:06
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/57527; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
25 words
A substantially pure synthetic peptide, or a nontoxic addition salt of a synthetic peptide, having the formula: ##STR8## wherein R 35 is Glu or Lys.
Claim 2
Dependent Claim
25 words
A substantially pure synthetic peptide, or a nontoxic addition salt of a synthetic peptide, having the formula: ##STR8## wherein R 35 is Glu or Lys.
Claim 3
Dependent Claim
10 words
The peptide of claim 1 wherein R 35 is Glu.
Claim 4
Dependent Claim
10 words
The peptide of claim 1 wherein R 35 is Lys.
Claim 5
Dependent Claim
48 words
A pharmaceutical composition for lowering blood pressure or gastric acid secretion in mammals comprising an effective amount of a substantially pure peptide, or a nontoxic addition salt thereof, having the formula: ##STR9## wherein R 35 is Glu or Lys; and a pharmaceutically acceptable liquid or solid carrier therefor.
Claim 6
Dependent Claim
48 words
A pharmaceutical composition for lowering blood pressure or gastric acid secretion in mammals comprising an effective amount of a substantially pure peptide, or a nontoxic addition salt thereof, having the formula: ##STR9## wherein R 35 is Glu or Lys; and a pharmaceutically acceptable liquid or solid carrier therefor.
Claim 7
Dependent Claim
10 words
The composition of claim 4 wherein R 35 is Glu.
Claim 8
Dependent Claim
10 words
The composition of claim 4 wherein R 35 is Lys.
Claim 9
Independent Claim
46 words
A method for lowering the blood pressure or gastric acid secretion of a mammal, which method comprises administering to said mammal an effective amount of a substantially pure peptide, or a nontoxic addition salt thereof, having the formula: ##STR10## wherein R 35 is Gly or Lys.
Claim 10
Independent Claim
46 words
A method for lowering the blood pressure or gastric acid secretion of a mammal, which method comprises administering to said mammal an effective amount of a substantially pure peptide, or a nontoxic addition salt thereof, having the formula: ##STR10## wherein R 35 is Gly or Lys.
Claim 11
Dependent Claim
21 words
The method in accordance with claim 7 wherein said administering is carried out either orally, intravenously, subcutaneously, percutaneously, intracerebrospinally or intramuscularly.
Claim 12
Dependent Claim
25 words
The method of claim 7 wherein said administration is at a level of between about 1 and about 200 micrograms per Kg. of body weight.
Claim 13
Dependent Claim
10 words
The method of claim 7 wherein R 35 is Glu.
Claim 14
Dependent Claim
10 words
The method of claim 7 wherein R 35 is Lys.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-22 | 1989-01-21 | 1989-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-22 | 1993-01-21 | 1993-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-22 | 1997-01-21 | 1997-07-23 | $7700.00 | Window Closed / Lapsed |