Patent US4537878A successfully refreshed from Google Patents.
US4537878A
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Process for using endogenous enkephalins and endorphins to stimulate the immune system
Assignee: Tni Pharmaceuticals Inc
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Filing: 1984-04-06
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Granted: 1985-08-27
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Expires: 2004-04-06
Abstract
Abstract A process of stimulating and promoting the natural immune system (T cells and NK cells) resisting and inhibiting the growth of tumorous cells as well as resisting infections (virus bacteria, and fungi) is disclosed. Endogenous endorphins are disclosed as the agent for stimulating the immune system.
Inventors
- 👤 Nicholas P. Plotnikoff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 11:46
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/33
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
21 words
A process for stimulating the T-cell and NK cell immune activity comprising the step of administering in vivo an endogenous endorphin.
Claim 2
Dependent Claim
21 words
A process for stimulating the T-cell and NK cell immune activity comprising the step of administering in vivo an endogenous endorphin.
Claim 3
Dependent Claim
27 words
A process of claim 1 wherein said endogenous endorphin is selected from the group consisting of beta-endorphin [61-91] and peptides of which beta-endorphin [61-91] is the precursor.
Claim 4
Dependent Claim
31 words
A process of claim 1 wherein said endogenous endorphin is selected from the group consisting of the following: peptides; Tyr-Gly-Gly-Phe-Met; Tyr-Gly-Gly-Phe-Leu; Tyr-Gly-Gly-Phe-Leu-Arg; Tyr-Gly-Gly-Phe-Met-Arg; Tyr-Gly-Gly-Phe-Met-Lys; Tyr-Gly-Gly-Phe-Met-Arg-Arg; Tyr-Gly-Gly-Phe-Met-Arg-Phe; Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu; Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys; Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.
Claim 5
Dependent Claim
11 words
A process of claim 1 wherein said endogenous endorphin is leucine-enkephalin.
Claim 6
Dependent Claim
11 words
A process of claim 1 wherein said endogenous endorphin is methionine-enkephalin.
Claim 7
Dependent Claim
22 words
A process of claim 4 or 5 wherein said enkephalin is administered in the range from about 0.001 to about 30 mg/kg.
Claim 8
Dependent Claim
23 words
A process of claim 1 wherein endogenous endorphin is administered in a dosage range from about 0.25 mg/kg to about 10 -14 mg/kg.
Claim 9
Dependent Claim
23 words
A process of claim 2 wherein endogenous endorphin is administered in a dosage range from about 0.25 mg/kg to about 10 -14 mg/kg.
Claim 10
Dependent Claim
23 words
A process of claim 3 wherein endogenous endorphin is administered in a dosage range from about 0.25 mg/kg to about 10 -14 mg/kg.
Claim 11
Dependent Claim
23 words
A process of claim 4 wherein said leucine-enkephalin is administered in a dosage range from about 0.25 mg/kg to about 10 -14 mg/kg.
Claim 12
Dependent Claim
23 words
A process of claim 4 wherein said methionine-enkephalin is administered in a dosage range from about 0.25 mg/kg to about 10 -14 mg/kg.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-26 | 1989-02-25 | 1989-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-26 | 1993-02-25 | 1993-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-26 | 1997-02-25 | 1997-08-27 | $7700.00 | Window Closed / Lapsed |