Film-forming composition containing an antimicrobial agent and methods

Claim 1

A dermatologically acceptable, film-forming composition, comprising: (a) a film-forming polymer which is the reaction product of (i) a prepolymer having a plurality of isocyanate functionalities, said prepolymer being the reaction product of a polyisocyanate, a major amount of which by weight is diisocyanate, and an isocyanate-reactive compound having a plurality of functionalities selected from the group consisting of a hydroxy group, a primary amine group, a secondary amine group, a thiol group, and a combination of at least two of the foregoing, a major amount of said isocyanate-reactive compound being difunctional with respect to said functionalities contained therein; (ii) a polyvinylpyrrolidone polymer which is the free-radical polymerization reaction product of at least n-vinylpyrrolidone and a vinyl-functional compound; and (iii) a chain-extender for said prepolymer and said polyvinylpyrrolidone polymer, said chain-extender having a plurality of functionalities selected from the group consisting of a hydroxy group, a primary amine group, a secondary amine group, a thiol group, and a combination of at least two of the foregoing, a major amount of said chain-extender being difunctional with respect to said functionalities contained therein; said vinyl-functional compound being further characterized in that it contains a functionality having reactivity with said chain-extender which is substantially equivalent to reactivity of the isocyanate functionalities of said prepolymer with said chain-extender; and (b) as an antimicrobial agent, iodine which forms a complex with said film-forming polymer; said composition when applied to skin from a fugitive solvent being capable of forming a substantially water-insoluble, substantially tack-free, flexible film which adheres to skin, releases iodine, when said film is in contact with the skin, and exhibits an elongation of between about 150% and 1000%.