Fine particulate for use in clinical testing and a process for producing thereof

Claim 2

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5 to 20 microns and an aldehyde group on the surface by exposing to light or ionizing radiation, at temperatures in the range of between 5° and -100° C., a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule while maintaining said monomer at temperatures within said temperature range.

Claim 3

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5° to 20 microns and an aldehyde group on the surface by exposing to light or ionizing radiation, at temperatures between 5° and -100° C., a system comprising a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule and at least one glass-forming, polymerizable vinyl monomer, while maintaining said system at temperatures within said temperature range.

Claim 4

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5° to 20 microns and an aldehyde group on the surface by exposing to light or ionizing radiation, at temperatures between 5° and -100° C., a system comprising a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule and at least one glass-forming, polymerizable vinyl monomer, while maintaining said system at temperatures within said temperature range.

Claim 5

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5 to 20 microns and an aldehyde group on the surface by exposing to light or ionizing radiation, at temperatures between 5° and -100° C., an aqueous solution containing a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule and a particle stabilizer selected from the group consisting of water-soluble polymers and surfactants, while maintaining said system at temperatures within said temperature range.

Claim 6

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5 to 20 microns and an aldehyde group on the surface by exposing to light or ionizing radiation, at temperatures between 5° and -100° C., an aqueous solution containing a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule and a particle stabilizer selected from the group consisting of water-soluble polymers and surfactants, while maintaining said system at temperatures within said temperature range.

Claim 7

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5 to 20 microns and an aldehyde group on the surface which is sensitized with a biologically active material by exposing to light or ionizing radiation, at temperatures between 5° and -100° C., a system containing a biologically active material plus a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule, or a combination of said polymer with a glass-forming, polymerizable vinyl monomer or a particle stabilizer selected from the group consisting of water-soluble polymers and surfactants, while maintaining said system at temperatures within said temperature range.

Claim 8

A process for producing a fine particulate carrier for use in clinical testing having a generally uniform size within the range of 0.5 to 20 microns and an aldehyde group on the surface which is sensitized with a biologically active material by exposing to light or ionizing radiation, at temperatures between 5° and -100° C., a system containing a biologically active material plus a polymerizable monomer having an aldehyde group and a polymerizable double bond in the same molecule, or a combination of said polymer with a glass-forming, polymerizable vinyl monomer or a particle stabilizer selected from the group consisting of water-soluble polymers and surfactants, while maintaining said system at temperatures within said temperature range.

Claim 9

A process according to claim 1 wherein the dosage of radiation applied is 10 4-10 6 R.

Claim 10

A process according to claim 2 wherein the dosage of radiation applied is 10 4 -10 6 R.

Claim 11

A process according to claim 3 wherein the dosage of radiation applied is 10 4 -10 6 R, and wherein said particle stabilizer is present in an amount not more than about 0.5% by weight of the reaction system.

Claim 12

A process according to claim 4 wherein the dosage of radiation applied is 10 4 -10 6 R, and wherein said particle stabilizer is present in an amount not more than about 0.5% by weight of the reaction system.

Claim 13

A procss according to claim 1 wherein said polymerizable monomer having an aldehyde group and a polymerizable double bond is selected from the group consisting of croton aldehyde, methacrolein and citral.

Claim 14

A process according to claim 2 wherein said polymerizable monomer having an aldehyde group and a polymerizable double bond is selected from the group consisting of croton aldehyde, methacrolein and citral.

Claim 15

A process according to claim 3 wherein said polymerizable monomer having an aldehyde group and a polymerizable double bond is selected from the group consisting of croton aldehyde, methacrolein and citral.

Claim 16

A process according to claim 4 wherein said polymerizable monomer having an aldehyde group and a polymerizable double bond is selected from the group consisting of croton aldehyde, methacrolein and citral.

Claim 17

A process according to claim 1 further comprising adding a biologically active material to said fine particulate carrier while maintaining a temperature no greater than about 10° C. and exposing to light or ionizing radiation to fix the biologically active material to the fine particulate carrier.

Claim 18

A process according to claim 2 further comprising adding a biologically active material to said fine particulate carrier while maintaining a temperature no greater than about 10° C. and exposing to light or ionizing radiation to fix the biologically active material to the fine particulate carrier.

Claim 19

A process according to claim 3 further comprising adding a biologically active material to said fine particulate carrier while maintaining a temperature no greater than about 10° C. and exposing to light or ionizing radiation to fix the biologically active material to the fine particulate carrier.