Patent US4585790A successfully refreshed from Google Patents.
US4585790A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions
Assignee: Glaxo Group Ltd
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Filing: 1984-05-11
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Granted: 1986-04-29
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Expires: 2004-05-11
Abstract
Abstract Aqueous formulations of raniditine have been found to have enhanced shelf life provided that they are formulated with a pH in the range 6.5-7.5. Suitable aqueous formulations include injections for intravenous and intramuscular administration, continuous infusions and oral preparations such as syrups.
Inventors
- 👤 John M. Padfield
- 👤 Ian K. Winterborn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:07
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61K47/00; A61K47/02; A61K9/0012; A61K9/0019; A61P; A61P43/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
42 words
A pharmaceutical composition which is an aqueous formulation containing an effective amount of ranitidine and/or one or more physiologically acceptable salts thereof for treatment of conditions mediated through histamine H 2 -receptors, said formulation having a pH within the range of 6.5-7.5.
Claim 2
Dependent Claim
42 words
A pharmaceutical composition which is an aqueous formulation containing an effective amount of ranitidine and/or one or more physiologically acceptable salts thereof for treatment of conditions mediated through histamine H 2 -receptors, said formulation having a pH within the range of 6.5-7.5.
Claim 3
Dependent Claim
16 words
A pharmaceutical composition according to claim 1 having a pH in the range 6.7 to 7.3.
Claim 4
Dependent Claim
16 words
A pharmaceutical composition according to claim 1 having a pH in the range 6.8 to 7.1.
Claim 5
Dependent Claim
19 words
A pharmaceutical composition according to claim 1 in which said pH is adjusted by means of suitable buffer salts.
Claim 6
Dependent Claim
27 words
A pharmaceutical composition according to claim 4 in which said buffer salts are potassium dihydrogen orthophosphate and disodium hydrogen orthophosphate or citric acid and disodium hydrogen orthophosphate.
Claim 7
Dependent Claim
14 words
A pharmaceutical composition according to claim 1 in a form suitable for parenteral administration.
Claim 8
Dependent Claim
24 words
A pharmaceutical composition according to claim 6 in a form suitable for injection and containing 10 to 100 mg/ml ranitidine, expressed as free base.
Claim 9
Dependent Claim
23 words
A pharmaceutical composition according to claim 6 in a form suitable for continuous infusion and containing 0.1-2.0 mg/ml raniditine, expressed as free base.
Claim 10
Dependent Claim
14 words
A pharmaceutical composition according to claim 1 in a form suitable for oral administration.
Claim 11
Dependent Claim
14 words
A pharmaceutical composition according to claim 9 containing 20-400 mg per 10 ml dose.
Claim 12
Dependent Claim
16 words
A pharmaceutical composition according to claim 1 containing ranitidine in the form of its hydrochloride salt.
Claim 13
Dependent Claim
39 words
A process for the production of a composition of claim 1 suitable for parenteral administration, which comprises dissolving ranitidine and/or one or more physiologically acceptable salts thereof and said remaining constituents in water suitable for injection, followed by sterilisation.
Claim 14
Dependent Claim
42 words
A process for the production of a composition of claim 1 suitable for oral administration which comprises adding an aqueous solution of ranitidine and/or one or more physiologically acceptable salts thereof to an aqueous solution or dispersion of a viscosity enhancing agent.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |