Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Claim 1

A compound of the formula ##STR17## wherein R is --CO--CH 3 , --CHOH--CH 3 , --CO--CH 2 OH, or --CHOH--CH 2 OH; hydroxy; a 1 to 3 carbon alkyl; a 1 to 3 carbon terminal hydroxyalkyl; a 2 to 7 carbon organic acid ester or diester of --CO--CH 2 OH, --CHOH--CH 2 OH, or --CHOH--CH 3 ; the groups --COCH 2 OH, --CHOHCH 2 OH or --CHOHCH 3 having a 1 to 6 carbon alkyl or aryl ether replacement of one or more hydroxyls; or 13-ketimine derivative of --CO--CH 3 or --CO--CH 2 OH; Y is methoxy or hydrogen; X is ═O or ═NH; R' and R" together are a hydrogen and a hydroxy, both are hydrogens, or R' is O-methoxy and R" is hydrogen; B is CN, or B and the hydrogen bonded to the same carbon taken together are ═O; or B and R' taken together are the oxygen bridge --O--; and A is cyano; Z is oxygen, sulfur, CH 2 , or ##STR18## wherein R'" is a 1 to 3 carbon alkyl, and the pharmaceutically acceptable acid addition salts therof.