US4591571A
Expired / Lapsed
US
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Fine carrier particles sensitized with acylated antibody for antigen detection
Assignee: Morinaga Milk Industry Co Ltd
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Filing: 1984-04-18
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Granted: 1986-05-27
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Expires: 2004-04-18
Abstract
Abstract Reagents for detecting antigen contained in body fluid or urine according to the immunological agglutination or agglutination inhibition reaction and comprising an antibody adsorbed on fine carrier particle to be sensitized as an effective constituent, and is characterized by acylating said antibody. Owing to such acylation, the reagent can correctly detect antigen without any influence of substance contained in sample which has inevitably caused nonspecific agglutination reaction according to the prior art.
Inventors
- 👤 Morio Kuboyama
- 👤 Yoshitsugu Harada
- 👤 Akio Kawashiri
- 👤 Eiji Takahashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:18
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54393; G01N33/531; Y; Y10; Y10S; Y10S436/00; Y10S436/825
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
In a reagent comprising antibody-sensitized fine carrier particles for detecting antigen in body fluids by agglutination or agglutination inhibition, the improvement comprising: antibody-sensitized fine carrier particles wherein the antibody has been chemically modified with an acylating agent.
Claim 2
Dependent Claim
37 words
In a reagent comprising antibody-sensitized fine carrier particles for detecting antigen in body fluids by agglutination or agglutination inhibition, the improvement comprising: antibody-sensitized fine carrier particles wherein the antibody has been chemically modified with an acylating agent.
Claim 3
Dependent Claim
28 words
The reagent according to claim 1, wherein the acylating agent is selected from the group consisting of monocarboxylic anhydrides, dicarboxylic anhydrides, polycarboxylic anhydrides, halides thereof and esters thereof.
Claim 4
Dependent Claim
24 words
The reagent according to claim 2, wherein the acylating agent is selected from the group consisting of anhydrides of succinic, maleic and acetic acids.
Claim 5
Dependent Claim
26 words
The reagent according to claim 1, wherein the antibody-sensitized fine carrier particles are suspended in a buffer solution of a concentration range of 0.01-3.0% by weight.
Claim 6
Dependent Claim
15 words
The reagent according to claim 4, wherein the pH of the buffer solution is 6-10.
Claim 7
Dependent Claim
17 words
The reagent according to claim 1 further comprising an immunologically inert protein and/or saccharide as a stabilizer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-26 | 1989-11-25 | 1990-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-26 | 1993-11-25 | 1994-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-26 | 1997-11-25 | 1998-05-27 | $7700.00 | Window Closed / Lapsed |