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US4604404A
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Antiviral sulfonated naphthalene formaldehyde condensation polymers
Assignee: AH Robins Co Inc
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Filing: 1985-04-03
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Granted: 1986-08-05
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Expires: 2005-04-03
Abstract
Abstract A method is disclosed for combating Herpes simplex viruses, Types I and II, which comprises topically applying and antiviral arylsulfonic acid polymer to the animal tissue under attack. Bacterial infections are also affectively treated.
Inventors
- 👤 Harry R. Munson, Jr.
- 👤 Robert W. Tankersley, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:25
CPC Classifications
A; A61; A61Q; A61Q17/00; A61Q17/005; A61K; A61K31/00; A61K31/74; A61K31/795; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61Q11/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
195 words
A method of treating viral infections caused by Type I or Type II Herpes simplex viruses comprising topically administering to infected tissue of a living animal under attack by said virus an effective amount of an arylsulfonic acid polymer having a repeating unit selected from the group consisting of the following structures: ##STR2## wherein R 1 and R 2 are selected from the group consisting of hydrogen, alkyl having 1 to 20 carbon atoms, alkoxy having 1 to 20 carbon atoms, fluorine, chlorine and bromine; R 3 is hydrogen, alkoxy having 1 to 20 carbon atoms; X is selected from the group consisting of a direct covalent bond between the aromatic rings, a loweralkylene having 1 to 5 carbon atoms, a lower alkylene having 2 to 5 carbon atoms, oxygen, sulfur, and --O(CH 2 ) n O-- wherein n is an integer from 2 to 20; p is from about 0.4 to about 1.2; the sum of q and r is from about 0.8 to about 2.4; and M is selected from the group consisting of lithium, sodium, potassium, calcium, magnesium, zinc, aluminum, hydrogen, ammonium and substituted ammonium ions derived from pharmaceutically acceptable organic amines.
Claim 2
Independent Claim
195 words
A method of treating viral infections caused by Type I or Type II Herpes simplex viruses comprising topically administering to infected tissue of a living animal under attack by said virus an effective amount of an arylsulfonic acid polymer having a repeating unit selected from the group consisting of the following structures: ##STR2## wherein R 1 and R 2 are selected from the group consisting of hydrogen, alkyl having 1 to 20 carbon atoms, alkoxy having 1 to 20 carbon atoms, fluorine, chlorine and bromine; R 3 is hydrogen, alkoxy having 1 to 20 carbon atoms; X is selected from the group consisting of a direct covalent bond between the aromatic rings, a loweralkylene having 1 to 5 carbon atoms, a lower alkylene having 2 to 5 carbon atoms, oxygen, sulfur, and --O(CH 2 ) n O-- wherein n is an integer from 2 to 20; p is from about 0.4 to about 1.2; the sum of q and r is from about 0.8 to about 2.4; and M is selected from the group consisting of lithium, sodium, potassium, calcium, magnesium, zinc, aluminum, hydrogen, ammonium and substituted ammonium ions derived from pharmaceutically acceptable organic amines.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein said arylsulfonic acid polymer is a condensation polymer of an arylsulfonic acid with formaldehyde.
Claim 4
Dependent Claim
14 words
The method according to claim 2 wherein said arylsulfonic acid is naphthelene sulfonic acid.
Claim 5
Dependent Claim
21 words
The method according to claim 3 wherein said sulfonic acid groups are in the form of a sodium or zinc salt.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein said viral infection causes venereal disease in humans.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-04 | 1990-02-03 | 1990-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-04 | 1994-02-03 | 1994-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-04 | 1998-02-03 | 1998-08-05 | $7700.00 | Window Closed / Lapsed |