Patent US4622188A successfully refreshed from Google Patents.
US4622188A
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Method for manufacturing liposomes
Assignee: Dade Behring Inc
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Filing: 1984-12-21
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Granted: 1986-11-11
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Expires: 2004-12-21
Abstract
Abstract A method and apparatus for manufacturing liposomes is characterized by optically monitoring the light transmission of a liposome precursor solution and controlling the flow rate and/or temperature of the precursor solution and/or a dialysis buffer solution in accordance therewith.
Inventors
- 👤 Marina Adamich
- 👤 David T. Bach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; Y; Y10; Y10S; Y10S436/00; Y10S436/829
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
68 words
A method for manufacturing liposomes comprising the steps of: (a) relatively moving a dialysis buffer solution with respect to a liposome precursor solution to create a gradient across a permeable barrier therebetween and thereby cause the formation of liposomes within the precursor solution; and (b) optically monitoring the light transmission of the precursor solution to control the relative movement of the dialysis and precursor solutions in accordance therewith.
Claim 2
Independent Claim
68 words
A method for manufacturing liposomes comprising the steps of: (a) relatively moving a dialysis buffer solution with respect to a liposome precursor solution to create a gradient across a permeable barrier therebetween and thereby cause the formation of liposomes within the precursor solution; and (b) optically monitoring the light transmission of the precursor solution to control the relative movement of the dialysis and precursor solutions in accordance therewith.
Claim 3
Dependent Claim
39 words
The method of claim 1 further comprising the step of: (c) terminating the relative movement of the dialysis and precursor solutions when the light transmission of the precursor solution reaches a predetermined stable level for a predetermined time period.
Claim 4
Dependent Claim
36 words
The method of claim 1 further comprising the step of: (d) controlling the temperature of one of the precursor or dialysis solutions in accordance with the signal representative of the light transmission of the precursor solution.
Claim 5
Dependent Claim
36 words
The method of claim 2 further comprising the step of: (e) controlling the temperature of one of the precursor or dialysis solutions in accordance with the signal representative of the light transmission of the precursor solution.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-10 | 1990-05-12 | 1990-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-10 | 1994-05-12 | 1994-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-10 | 1998-05-12 | 1998-11-11 | $7700.00 | Window Closed / Lapsed |