Patent US4643898A successfully refreshed from Google Patents.
US4643898A
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Magnesium trisilicate suitable for preparation of medicament adsorbates of nutritional supplements and laxatives
Assignee: Warner Lambert Co LLC
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Filing: 1985-12-19
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Granted: 1987-02-17
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Expires: 2005-12-19
Abstract
Abstract A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is a nutritional supplement or laxative.
Inventors
- 👤 David Peters
- 👤 John Denick, Jr.
- 👤 Anil K. Talwar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 11:03
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/141; A61K9/143
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
85 words
A medicament adsorbate which comprises magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces, and containing adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug wherein the medicament drug is selected from the group of nutritional supplements and laxatives consisting of niacin, panthothenic acid, vitamin B6, thiamine hydrochloride, riboflavin, potassium iodide, potassium chloride, cupric sulfate, ferrous sulfate, phenolphthalein, danthron, bisocadyl, pamabrom and mixtures thereof.
Claim 2
Dependent Claim
85 words
A medicament adsorbate which comprises magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces, and containing adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug wherein the medicament drug is selected from the group of nutritional supplements and laxatives consisting of niacin, panthothenic acid, vitamin B6, thiamine hydrochloride, riboflavin, potassium iodide, potassium chloride, cupric sulfate, ferrous sulfate, phenolphthalein, danthron, bisocadyl, pamabrom and mixtures thereof.
Claim 3
Dependent Claim
25 words
The adsorbate of claim 1 wherein the medicament drug is present in the amount of about 5% to about 15% by weight of the adsorbate.
Claim 4
Dependent Claim
25 words
The adsorbate of claim 1 wherein the magnesium trisilicate has a surface area of about 440 m 2 /g to about 600 m 2 /g.
Claim 5
Dependent Claim
102 words
A process for preparing a medicament adsorbate which comprises dissolving a medicament drug selected from the group of nutritional supplements and laxatives consisting of niacin, panthothenic acid, vitamin B6, thiamine hydrochloride, riboflavin, potassium iodide, potassium chloride, cupric sulfate, ferrous sulfate, phenolphthalein, danthron, bisocadyl, pamabrom and mixtures thereof in solvent, admixing magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces therewith to prepare a mass having a homogenous consistency to enable migration of the medicament drug within the interstitial spaces of the magnesium trisilicate and recovering the medicament adsorbate product.
Claim 6
Dependent Claim
102 words
A process for preparing a medicament adsorbate which comprises dissolving a medicament drug selected from the group of nutritional supplements and laxatives consisting of niacin, panthothenic acid, vitamin B6, thiamine hydrochloride, riboflavin, potassium iodide, potassium chloride, cupric sulfate, ferrous sulfate, phenolphthalein, danthron, bisocadyl, pamabrom and mixtures thereof in solvent, admixing magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces therewith to prepare a mass having a homogenous consistency to enable migration of the medicament drug within the interstitial spaces of the magnesium trisilicate and recovering the medicament adsorbate product.
Claim 7
Dependent Claim
44 words
The process of claim 4 which comprises employing about 15% to about 35% by weight solvent to prepare a granulated admixture containing the medicament drug and magnesium trisilicate adsorbate which is dried to a final moisture content of about 5% to about 20% weight.
Claim 8
Dependent Claim
36 words
The process of claim 4 which comprises employing about 30% to about 60% solvent by weight of the total composition to prepare a slurry and thereafter removing the solvent from the slurry to form a paste.
Claim 9
Dependent Claim
17 words
The process of claim 6 wherein the paste is dried and recovered as a free flowing powder.
References Cited (Backward Citations)
US2881113A
Cited
US3352752A
Cited
US3337402A
Cited
US3432593A
Cited
US3449266A
Cited
US3567819A
Cited
US3636200A
Cited
US4029797A
Cited
GB1578541A
Cited
US4401674A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-16 | 1990-08-18 | 1991-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-16 | 1994-08-18 | 1995-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-16 | 1998-08-18 | 1999-02-17 | $7700.00 | Window Closed / Lapsed |