Patent US2169409A successfully refreshed from Google Patents.
Patent US3384881A successfully refreshed from Google Patents.
Patent US3190774A successfully refreshed from Google Patents.
Patent US916556A successfully refreshed from Google Patents.
Patent US4645774A successfully refreshed from Google Patents.
US4645774A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
•
Filing: 1985-12-02
•
Granted: 1987-02-24
•
Expires: 2005-12-02
Abstract
Abstract The invention relates to new aminoethoxybenzylalcohol derivatives of the formula (I) <IMAGE> (I) wherein R1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms; R2 is halogen, trihalomethyl, or alkoxy having from one to 4 carbon atoms; R3 and R4 stand for methyl or together with the adjacent nitrogen form an up to 8-membered ring optionally containing oxygen, and acid addition or quaternary ammonium salts thereof. The compounds of formula (I) are pharmacologically active, thus show enzyme-inducing effect. The pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
Inventors
- 👤 Edit Toth
- 👤 Jozsef Torley
- 👤 Eva Palosi
- 👤 Szabolcs Szeberenyi
- 👤 Laszlo Szporny
- 👤 Sandor Gorog
- 👤 Istvan Hajdu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 19:45
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; A; A61; A61P; A61P43/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
53 words
A compound of the Formula (I) ##STR12## wherein R 1 is hydrogen; R 2 is halo, trihalomethyl, or C 1 to C 4 alkoxy; and R 3 and R 4 together with the adjacent nitrogen atom form a piperidinyl, or pyrrolidinyl, group; or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Claim 2
Dependent Claim
53 words
A compound of the Formula (I) ##STR12## wherein R 1 is hydrogen; R 2 is halo, trihalomethyl, or C 1 to C 4 alkoxy; and R 3 and R 4 together with the adjacent nitrogen atom form a piperidinyl, or pyrrolidinyl, group; or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Claim 3
Dependent Claim
43 words
The compound of the Formula (I) defined in claim 1 selected from the group consisting of: (a) alpha-ethyl-alpha-(2-methoxy-phenyl)-4-[2-pyrrolidin-l-yl)-ethoxy]-benzyl alcohol; (b) alpha-ethyl-alpha-(4-fluorophenyl)-4-[2-piperidin-l-yl-ethoxy]-benzyl alcohol; (c) alpha-ethyl-alpha-(3-trifluoromethyl-phenyl)-4-[2-(piperidin-l-yl)-ethoxy]-benzyl alcohol; (d) alpha-ethyl-alpha-(3-chloro-phenyl)-4-[2-piperidin-l-yl)-ethoxy]-benzyl alcohol; and (e) alpha-ethyl-alpha-(2-methoxyphenyl)-4-[2-piperidin-l-yl)-ethoxy]-benzyl alcohol; or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Claim 4
Dependent Claim
18 words
Alpha-ethyl-alpha-(3-trifluoromethyl-phenyl)-4-[2-(piperidin-l-yl)-ethoxy]-benzyl alcohol as defined in claim 1 or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Claim 5
Dependent Claim
18 words
Alpha-ethyl-alpha-(2-methoxyphenyl)-4-[2-pyrrolidin-l-yl)-ethoxy]-benzyl alcohol as defined in claim 1 or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Claim 6
Dependent Claim
18 words
Alpha-ethyl-alpha-(4-fluorophenyl)-4-[2-(piperidin-l-yl)-ethoxy]-benzyl alcohol as defined in claim 1 or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Claim 7
Dependent Claim
48 words
A pharmaceutical composition for inducing the polysubstrate liver monooxygenase enzyme system containing a pharmaceutically effective amount of the compound of the Formula (I) as defined in claim 1 or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, together with a pharmaceutically acceptable carrier or auxiliary substance.
Claim 8
Dependent Claim
45 words
A method of inducing the polysubstrate liver monooxygenase enzyme system in a susceptible subject which comprises administering to said subject an effective amount of the compound of the Formula (I) defined in claim 1 or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-23 | 1990-08-25 | 1991-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-23 | 1994-08-25 | 1995-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-23 | 1998-08-25 | 1999-02-24 | $7700.00 | Window Closed / Lapsed |