US4647280A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Binder for low density lipoproteins
Assignee: Akzo NV
•
Filing: 1986-07-02
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Granted: 1987-03-03
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Expires: 2006-07-02
Abstract
Abstract A binder for low density lipoproteins (LDL) consisting of sulphated polyvinyl alcohol which is cross-linked by the chemical or the physical route to a waterinsoluble product. The binder may be in the form of a hydrogel which is applied or not to a carrier or it may be present on the surface of a polyvinyl alcohol fibre which is preferably in the form of tape having a thickness of 0,1 to 2 μm and a width of 0,5 to 6 μm. The fibre shaped binder is prepared by successively cross-linking with an acidified aqueous solution of glutardialdehyde and sulphating with chlorosulphonic acid.
Inventors
- 👤 Nico Maaskant
- 👤 Adriaan Bantjes
- 👤 Hermanus J. M. Kempen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:40
CPC Classifications
C; C08; C08J; C08J3/00; C08J3/28; A; A61; A61P; A61P3/00; A61P3/06; C08F; C08F8/00; C08F8/18; C08F8/28; C08F8/34; C08F8/36; C08F2810/00; C08F2810/20; C08J2329/00; C08J2329/02; C08J2329/04; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165; Y10T436/106664
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
41 words
Method for the clinical removal of low density lipoproteins (LDL) from blood or blood serum in an extracorporeal treatment, comprising binding said low density lipoproteins to a binder consisting of sulphated polyvinyl alcohol which is cross-linked to a water insoluble product.
Claim 2
Dependent Claim
41 words
Method for the clinical removal of low density lipoproteins (LDL) from blood or blood serum in an extracorporeal treatment, comprising binding said low density lipoproteins to a binder consisting of sulphated polyvinyl alcohol which is cross-linked to a water insoluble product.
Claim 3
Dependent Claim
18 words
Method according to claim 1, characterized in that at least 20% of the vinyl alcohol groups are sulphated.
Claim 4
Dependent Claim
18 words
Method according to claim 1, characterized in that at least 50% of the vinyl alcohol groups are sulphated.
Claim 5
Dependent Claim
18 words
Method according to claim 1, characterized in that at least 65% of the vinyl alcohol groups are sulphated.
Claim 6
Dependent Claim
25 words
Method according to claim 1, characterized in that the binder is in the form of a hydrogel which is applied or not to a carrier.
Claim 7
Dependent Claim
35 words
Method according to claim 1, characterized in that the binder is so cross-linked that after swelling in a physiological salt solution the weight ratio of swollen gel to dry matter is 10 to 75 g/g.
Claim 8
Dependent Claim
35 words
Method according to claim 1, characterized in that the binder is so cross-linked that after swelling in a physiological salt solution the weight ratio of swollen gel to dry matter is 30 to 50 g/g.
Claim 9
Dependent Claim
20 words
Method according to claim 1, characterized in that the binder is present on the surface of a polyvinyl alcohol fiber.
Claim 10
Dependent Claim
33 words
Method according to claim 8, characterized in that the fiber is in the form of tape, and has a thickness of 0.1 to 2 μm and a width of 0.5 to 6 μm.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-02 | 1990-09-01 | 1991-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-02 | 1994-09-01 | 1995-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-02 | 1998-09-01 | 1999-03-03 | $7700.00 | Window Closed / Lapsed |