Patent US4650756A successfully refreshed from Google Patents.
US4650756A
Expired / Lapsed
US
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Monoclonal antibodies to cell surface antigens of human renal cancer
Assignee: Memorial Sloan Kettering Cancer Center
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Filing: 1981-08-31
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Granted: 1987-03-17
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Expires: 2001-08-31
Abstract
Abstract The preparation and use of monoclonal antibodies to human renal tumor cells is described. The monoclonal antibodies bind to glycoproteins of 160Kd, 120Kd and 115Kd, a glycolipid, a HLA heavy chain, group A blood and group B blood antigens.
Inventors
- 👤 Lloyd J. Old
- 👤 Kenneth O. Lloyd
- 👤 Herbert F. Oettgen
- 👤 Willet F. Whitmore
- 👤 Jerzy Szkudlarek
- 👤 Connie L. Finstad
- 👤 Donna Morrissey
- 👤 Shun-ichiro Ogata
- 👤 Ryuzo Ueda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 01:05
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3038; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/948; Y10S530/00; Y10S530/808; Y10S530/809; Y10S530/863; Y10S530/864
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
62 words
Antibody producing hybridoma cell lines characterized by the production of nonoclonal antibodies recognizing malignant human renal cells wherein said cell lines are selected from the group consisting of ATCC HB 9079, ATCC HB 8541, ATCC HB 9034, ATCC HB 9035, ATCC HB 8542, ATCC HB 8540, ATCC HB 9037, ATCC HB 9069, ATCC HB 9044, ATCC HB 8428, and ATCC HB 8429.
Claim 2
Dependent Claim
62 words
Antibody producing hybridoma cell lines characterized by the production of nonoclonal antibodies recognizing malignant human renal cells wherein said cell lines are selected from the group consisting of ATCC HB 9079, ATCC HB 8541, ATCC HB 9034, ATCC HB 9035, ATCC HB 8542, ATCC HB 8540, ATCC HB 9037, ATCC HB 9069, ATCC HB 9044, ATCC HB 8428, and ATCC HB 8429.
Claim 3
Dependent Claim
53 words
Monoclonal antibodies recognizing malignant human renal cells and produced by hybridoma cell lines selected from the group consisting of ATCC HB 9079, ATCC HB 8541, ATCC HB 9034, ATCC HB 9035, ATCC HB 8542, ATCC HB 8540, ATCC HB 9037, ATCC HB 9069, ATCC HB 9044, ATCC HB 8428, and ATCC HB 8429.
Claim 4
Dependent Claim
53 words
Monoclonal antibodies recognizing malignant human renal cells and produced by hybridoma cell lines selected from the group consisting of ATCC HB 9079, ATCC HB 8541, ATCC HB 9034, ATCC HB 9035, ATCC HB 8542, ATCC HB 8540, ATCC HB 9037, ATCC HB 9069, ATCC HB 9044, ATCC HB 8428, and ATCC HB 8429.
Claim 5
Dependent Claim
14 words
Monoclonal antibodies of claim 2 recognizing the gp160 antigenic system in human renal cells.
Claim 6
Dependent Claim
15 words
Monoclonal antibodies of claim 2 recognizing the S 25 antigenic system in human renal cells.
Claim 7
Dependent Claim
16 words
Monoclonal antibodies of claim 2 recognizing the gp120r or gp120nr antigenic system in human renal cells.
Claim 8
Dependent Claim
14 words
Monoclonal antibodies of claim 2 recognizing the gp115 antigenic system in human renal cells.
Claim 9
Dependent Claim
15 words
Monoclonal antibodies of claim 2 recognizing the V 1 antigenic system in human renal cells.
Claim 10
Dependent Claim
69 words
Method for differentiating between normal and malignant human renal cells which comprises contacting a human renal cell specimen with a human monoclonal antibody produced by a hybridoma cell line selected from the group consisting of ATCC HB 9079, ATCC HB 8541, ATCC HB 9034, ATCC HB 9035, ATCC HB 8542, ATCC HB 8540, ATCC HB 9037, ATCC HB 9069, ATCC HB 9044, ATCC HB 8428, and ATCC HB 8429.
Claim 11
Dependent Claim
69 words
Method for differentiating between normal and malignant human renal cells which comprises contacting a human renal cell specimen with a human monoclonal antibody produced by a hybridoma cell line selected from the group consisting of ATCC HB 9079, ATCC HB 8541, ATCC HB 9034, ATCC HB 9035, ATCC HB 8542, ATCC HB 8540, ATCC HB 9037, ATCC HB 9069, ATCC HB 9044, ATCC HB 8428, and ATCC HB 8429.
Claim 12
Dependent Claim
22 words
Method of claim 8 wherein said specimen is separately contacted with a plurality of said monoclonal antibodies each of which is different.
Claim 13
Dependent Claim
21 words
Monoclonal antibodies recognizing human renal cell antigenic systems selected from the group consisting of gp160, S25, gp120r, gp120nr, gp115 and V1.
Claim 14
Dependent Claim
21 words
Monoclonal antibodies recognizing human renal cell antigenic systems selected from the group consisting of gp160, S25, gp120r, gp120nr, gp115 and V1.
References Cited (Backward Citations)
US4172124A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |