Patent US4668665A successfully refreshed from Google Patents.
US4668665A
Expired / Lapsed
US
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Formulation of sucralfate
Assignee: Chugai Pharmaceutical Co Ltd
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Filing: 1985-09-10
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Granted: 1987-05-26
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Expires: 2005-09-10
Abstract
Abstract A storage-stable sucralfate-containing preparation which maintains its ability, even after extended periods of time, to form a viscous, sticky, paste-like material in the presence of gastric secretions is disclosed as well as the method of making same.
Inventors
- 👤 Kouji Ishihara
- 👤 Kazuo Igusa
- 👤 Toshichika Ogasawara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 08:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61P; A61P1/00; A61P1/04; A61P35/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
141 words
A storage-stable, sucralfate-containing composition which maintains its ability, even after extended periods of time of at least 15 days, to form a viscous, sticky, paste-like composition in the presence of artificial gastric secretion, which contains, in addition to sucralfate, a material which helps to preserve the adhesive nature of sucralfate and the protective effects of sucralfate against acids, pepsin and bile salts wherein said material is an amino acid selected from glycine, alanine, valine, serine, proline, glutamine, asparagine, arginine, aminobutyric acid, ε-aminocaproic acid, glutamic acid, aspartic acid, lysine or histidine, or their acid and base addition salts, or a compound which contains in its structure an amino acid selected from pantothenic acid or N-glycylglycine or their acid and base addition salts, said composition containing said amino acid or compound in 0.5 to 50 weight percent based on the amount of sucralfate.
Claim 2
Dependent Claim
141 words
A storage-stable, sucralfate-containing composition which maintains its ability, even after extended periods of time of at least 15 days, to form a viscous, sticky, paste-like composition in the presence of artificial gastric secretion, which contains, in addition to sucralfate, a material which helps to preserve the adhesive nature of sucralfate and the protective effects of sucralfate against acids, pepsin and bile salts wherein said material is an amino acid selected from glycine, alanine, valine, serine, proline, glutamine, asparagine, arginine, aminobutyric acid, ε-aminocaproic acid, glutamic acid, aspartic acid, lysine or histidine, or their acid and base addition salts, or a compound which contains in its structure an amino acid selected from pantothenic acid or N-glycylglycine or their acid and base addition salts, said composition containing said amino acid or compound in 0.5 to 50 weight percent based on the amount of sucralfate.
Claim 3
Dependent Claim
24 words
The composition of claim 1 which contains said amino acid or compound in 1 to 10 weight percent based on the amount of sucralfate.
Claim 4
Dependent Claim
22 words
A pharmaceutically acceptable composition comprising an inert carrier and a mucosal protecting amount of a sucralfate composition as claimed in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-25 | 1990-11-24 | 1991-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-25 | 1994-11-24 | 1995-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-25 | 1998-11-24 | 1999-05-26 | $7700.00 | Window Closed / Lapsed |