N-(3-phenoxycinnamyl)acetohydroxamic acid

Abstract

Abstract Novel compounds of formula (I) Ar--(L--Ar').sub.q --(X).sub.k --(Y).sub.p --Q (I) wherein: k, p and q are independently 0 or 1; Ar represents either: (i) naphthyl, tetrahydronaphthyl, pyridyl or (ii) phenyl, optionally substituted, L is selected from --(CH 2 ) r -- (where r is 1-4), --O--, --CH 2 O--, --CH 2 S--, --OCH 2 --, --CONH--, --NHCO--, --CO-- and --CH 2 NH--, and, Ar' represents phenylene, thienylene or pyridylene optionally substituted, X represents oxygen, sulphur or carbonyl, Y is C 1-10 alkylene or C 1-10 alkenylene; Q represents a non-cyclic moiety selected from groups of formula ##STR1## in which one of m and n is 0 and the other is 1, R 1 and R 2 is selected from hydrogen, C 1-4 alkyl, amino, C 1-4 alkylamino, di-C 1-4 alkylamino, C 5-7 cycloalkylamino, C 5-7 cycloalkyl (C 1-4 alkyl) amino, anilino, N-C 1-4 alkylanilino or Q represents a cyclic moiety selected from 1-hydroxy-1,3-dihydroimidazol-2-one and groups of formula ##STR2## in which Z represents a C 2-5 alkylene chain in which one of the carbon atoms may be replaced by a hetero atom; and salts thereof.

Inventors

• 👤 Geoffrey Kneen
• 👤 William P. Jackson
• 👤 Peter J. Islip
• 👤 Peter J. Wates

Bibliographic Details