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US4739098A
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Ethynylphenyl-containing retinoic acid derivatives
Assignee: Allergan Inc
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Filing: 1986-09-22
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Granted: 1988-04-19
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Expires: 2006-09-22
Abstract
Abstract Retinoid-like activity is exhibited by compounds of the formula ##STR1## where n is 0-5 and A is H, lower alkyl, or --COOH or ester or amide thereof, --CH 2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or a pharmaceutically acceptable salt.
Inventors
- 👤 Roshantha A. S. Chandraratna
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:53
CPC Classifications
C; C07; C07C; C07C69/00; C07C69/612; C07C69/618; C07C403/00; C07C403/14; A; A61; A61P; A61P17/00; A61P27/00; A61P27/16; A61P29/00; A61P37/00; C07C403/06; C07C403/08; C07C403/10; C07C403/12; C07C403/20; C07C2601/00; C07C2601/12; C07C2601/16
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
44 words
A compound of the formula ##STR6## where n is 0-5 and A is H, lower alkyl, or --COOH or an ester or amide thereof: --CH 2 OH or an ether or ester derivative: or --CHO or an acetal derivative: or a pharmaceutically acceptable salt.
Claim 2
Dependent Claim
44 words
A compound of the formula ##STR6## where n is 0-5 and A is H, lower alkyl, or --COOH or an ester or amide thereof: --CH 2 OH or an ether or ester derivative: or --CHO or an acetal derivative: or a pharmaceutically acceptable salt.
Claim 3
Dependent Claim
9 words
A compound of claim 1 where n is 0.
Claim 4
Dependent Claim
21 words
A compound according to claim 2 where A is --COOH or an ester or amide, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
19 words
A compound according to claim 3 which is ethyl 4-[4'-(2",6",6"-trimethylcyclohex-1"-enyl)-but-3'-en-1'-ynyl]benzoate; or 4-[4'-(2",6",6"-trimethylcyclohex-1"-enyl)-but-3'-en-1'-ynyl]benzoic acid; or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
24 words
A compound according to claim 2 where A is --CH 2 OH or an ether or ester derivative, or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
21 words
A compound according to claim 2 where A is --CHO or an acetal derivative thereof, or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
10 words
A compound according to claim 1 wherein n is 1.
Claim 9
Dependent Claim
22 words
A compound according to claim 7 where A is --COOH or an ester or amide thereof, or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
10 words
A compound according to claim 1 where n is 2.
Claim 11
Dependent Claim
22 words
A compound according to claim 9 where A is --COOH or an ester or amide thereof, or a pharmaceutically acceptale salt thereof.
Claim 12
Dependent Claim
10 words
A compound according to claim 1 where n is 3.
Claim 13
Dependent Claim
22 words
A compound according to claim 11 where A is --COOH or an ester or amide thereof, or a pharmaceutically acceptable salt thereof.
Claim 14
Independent Claim
70 words
A method for treating psoriasis in a mammal which method comprises administering alone or in conjunction with a pharmaceutically acceptable excipient, a therapeutically effective amount of a compound of the formula ##STR7## where n is 0-5 and A is H, lower alkyl, or --COOH or an ester or amide thereof; --CH 2 OH or an ether or ester derivative; or --CHO or an acetal derivative; or a pharmaceutically acceptable salt.
Claim 15
Independent Claim
70 words
A method for treating psoriasis in a mammal which method comprises administering alone or in conjunction with a pharmaceutically acceptable excipient, a therapeutically effective amount of a compound of the formula ##STR7## where n is 0-5 and A is H, lower alkyl, or --COOH or an ester or amide thereof; --CH 2 OH or an ether or ester derivative; or --CHO or an acetal derivative; or a pharmaceutically acceptable salt.
Claim 16
Dependent Claim
53 words
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula ##STR8## where n is 0-5 and A is H, lower alkyl, or --COOH or an ester or amide thereof; --CH 2 OH or an ether or ester derivative; or --CHO or an acetal derivative; or a pharmaceutically acceptable salt.
Claim 17
Dependent Claim
53 words
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula ##STR8## where n is 0-5 and A is H, lower alkyl, or --COOH or an ester or amide thereof; --CH 2 OH or an ether or ester derivative; or --CHO or an acetal derivative; or a pharmaceutically acceptable salt.
Claim 18
Dependent Claim
19 words
A compound according to claim 3 which is ethyl 3-[4'-(2",6",6"-trimethylcyclohex-1"-enyl)-but-3'-en-1'-ynyl]benzoate; or 3-[4'-(2",6",6"-trimethylcyclohex-1"-enyl)-but-3'-en-1'-ynyl]benzoic acid, or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US4532343A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-19 | 1991-10-19 | 1992-04-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-19 | 1995-10-19 | 1996-04-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-19 | 1999-10-19 | 2000-04-19 | $7700.00 | Window Closed / Lapsed |