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US4744975A
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6-iodoethylated starch and process for preparing the same
Assignee: Nippon Universal Pharmaceutical Co Ltd
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Filing: 1986-05-20
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Granted: 1988-05-17
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Expires: 2006-05-20
Abstract
Abstract 6-Iodoethylated starch and process for preparing the same are disclosed. The 6-idodethylated starch contains one iodine attached per 5 glucose units. Said compound is useful as a contrast agent for X-ray examination, especially for opacifying the vascular os lymphatic vessel. Said compound is produced by reacting 6-hydroxyethylated starch with N-iodosuccinimide in the presence of triphenylphosphine.
Inventors
- 👤 Tetsuo Suami
- 👤 Masao Sako
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:55
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0442; C; C08; C08B; C08B31/00; C08B31/08; C08B31/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
78 words
A 6-iodoethylated starch containing one iodine attached per 5 glucose units characterized by the following physicochemical properties: Melting point: 165° C. (decomposed); Specific optic rotation: [α] D 22 +136° (C=1.45, H 2 O); IR: γ max KBr cm -1 ;3400, 2920, 1655, 1360, 1210, 1150, 1020, 685; Solubility in water: 0.5 g/ml; Elementary analysis: Calc'd % (for one iodine attached per 5 glucose units): C 41.07; H 5.50; I 12.05: Found %: C 37.31; H 5.42; I 12.47.
Claim 2
Dependent Claim
78 words
A 6-iodoethylated starch containing one iodine attached per 5 glucose units characterized by the following physicochemical properties: Melting point: 165° C. (decomposed); Specific optic rotation: [α] D 22 +136° (C=1.45, H 2 O); IR: γ max KBr cm -1 ;3400, 2920, 1655, 1360, 1210, 1150, 1020, 685; Solubility in water: 0.5 g/ml; Elementary analysis: Calc'd % (for one iodine attached per 5 glucose units): C 41.07; H 5.50; I 12.05: Found %: C 37.31; H 5.42; I 12.47.
Claim 3
Dependent Claim
22 words
A process for preparing 6-iodoethylated starch according to claim 1 which comprises reacting 6-hydroxyethylated starch with N-iodosuccinimide in the presence of triphenylphosphine.
Claim 4
Independent Claim
27 words
A method for opacifying a portion of a patient for x-ray examination comprising introducing into said portion an opacifying effective amount of the 6-iodoethylated starch of claim
Claim 5
Dependent Claim
27 words
The method of claim 3 wherein a vascular or a lymphatic vessel is to be opacified and the 6-iodoethylated starch is introduced by injection into said vessel.
Claim 6
Dependent Claim
16 words
The method of claim 3 wherein the x-ray examination is computer tomography or digital subtraction angiography.
Claim 7
Dependent Claim
22 words
A 6-iodoethylated starch containing approximately one iodine per 5 glucose units and having between about 12% up to 15% iodine by weight.
Claim 8
Dependent Claim
22 words
A 6-iodoethylated starch containing approximately one iodine per 5 glucose units and having between about 12% up to 15% iodine by weight.
Claim 9
Dependent Claim
10 words
The 6-iodoethylated starch of claim 6 containing about 12% iodine.
Claim 10
Dependent Claim
22 words
A process for preparing the 6-iodoethylated starch of claim 6 which comprises reacting 6-hydroxyethylated starch with N-iodosuccinimide in the presence of triphenylphosphine.
References Cited (Backward Citations)
US4119487A
Cited
US4167621A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |