US4769362A
Expired / Lapsed
US
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Increased vascular perfusion following administration of lipids
Assignee: ANGIO-MEDICAL Corp
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Filing: 1986-04-14
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Granted: 1988-09-06
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Expires: 2006-04-14
Abstract
Abstract Lipid containing molecules and compositions, including gangliosides and omental tissue extracts had previously been found to be effective in increasing angiogenesis. It has now been found that these same materials cause increased localized perfusion in mammals. A method for providing increased perfusion, using these compositions, is presented herein.
Inventors
- 👤 Nicholas Catsimpoolas
- 👤 Robert McCluer
- 👤 James Evans
- 👤 Robert S. Sinn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 04:53
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10; A; A61; A61K; A61K31/00; A61K31/66; A61K31/683; A61K31/685; A61K31/70; A61K31/715; A61K35/00; A61K35/12; A61K35/37; A61K35/38; A61P; A61P7/00; A61P9/00; A61P9/14
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
38 words
A method of improving localized vascular perfusion in mammals comprising administering to a mammal in need of improved localized vascular perfusion a therapeutically effective amount of a composition containing angiogenically effective lipid-containing molecules and a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
38 words
A method of improving localized vascular perfusion in mammals comprising administering to a mammal in need of improved localized vascular perfusion a therapeutically effective amount of a composition containing angiogenically effective lipid-containing molecules and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
16 words
A method as in claim 1, wherein said composition comprises an extract of mammalian omental tissue.
Claim 4
Dependent Claim
11 words
A method as in claim 1, wherein said composition comprises gangliosides.
Claim 5
Dependent Claim
12 words
A method as in claim 3, wherein said composition is administered intravenously.
Claim 6
Dependent Claim
17 words
A method as in claim 3, wherein said composition comprises a mixture of mono-, di-, and tri-sialogangliosides.
Claim 7
Dependent Claim
21 words
A method as in claim 5, wherein said mixture comprises mono-, di-, and tri-sialogangliosides in a ratio of 1:1:1 by weight.
Claim 8
Dependent Claim
16 words
A method as in claim 3, wherein said composition comprises a mixture of di- and tri-sialogangliosides.
Claim 9
Dependent Claim
19 words
A method as in claim 7, wherein said di- and tri-sialogangliosides are in a ratio of 1:2 by weight.
Claim 10
Dependent Claim
14 words
A method as in claim 3, wherein said mixture further comprises omental neutral lipids.
Claim 11
Dependent Claim
27 words
A method as in claim 1, wherein said composition is administered in an amount up to about 500 mg per kg of body weight of said mammal.
Claim 12
Independent Claim
14 words
A method as in claims 1 or 3, wherein said composition is administered subcutaneously.
Claim 13
Independent Claim
14 words
A method as in claims 1 or 3, wherein said composition is administered intramuscularly.
Claim 14
Dependent Claim
18 words
A method as in claim 1, wherein said composition comprises a mixture of mammalian omental extract and gangliosides.
Claim 15
Dependent Claim
27 words
A method as in claim 1, wherein said composition is administered to said mammal at a site removed from a site where improved vascular perfusion is desired.
Claim 16
Dependent Claim
20 words
A method as in claim 14, wherein said composition is administered to said mammal at a site of traumatized tissue.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-06 | 1992-03-07 | 1992-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-06 | 1996-03-07 | 1996-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-06 | 2000-03-07 | 2000-09-06 | $7700.00 | Window Closed / Lapsed |