US4793987A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilized radiolabelled compounds
Assignee: GE Healthcare Ltd
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Filing: 1986-04-25
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Granted: 1988-12-27
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Expires: 2006-04-25
Abstract
Abstract A stabilizer for radioactively labelled organic compounds has the general formula <IMAGE> where R is C1 to C4 alkylene which may be OH substituted, m is 0 or 1 (i.e. R may be absent or present), X is carboxyl or sulphonyl e.g. COOH or SO3H or a salt thereof and n is 1, 2 or 3. Radiolabelled compounds of biological origin, such as nucleotides and amino acids, may be stabilized either in solution or in the freeze-dried state. For example, L-[35S]methionine may be stabilized to prevent formation of a 47 KD band in protein transcription/translation experiments.
Inventors
- 👤 Alan Henderson
- 👤 Kenneth S. Bowler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:01
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; C07D213/80; A; A61; A61K; A61K51/00; A61K51/12; A61K51/1241; C07D213/24; C07D213/44; C07D213/52; C07D213/54; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/108331
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A composition comprising at least one radioactivity labelled organic compound selected from the group consisting of amino acid or nucleotide and a stabiliser therefor which stabiliser has the general formula ##STR3## where R is C1 to C4 alkylene which may be OH substituted m is 0 or 1 X is carboxyl or sulphonyl or a salt thereof, n is 1, 2 or 3.
Claim 2
Dependent Claim
63 words
A composition comprising at least one radioactivity labelled organic compound selected from the group consisting of amino acid or nucleotide and a stabiliser therefor which stabiliser has the general formula ##STR3## where R is C1 to C4 alkylene which may be OH substituted m is 0 or 1 X is carboxyl or sulphonyl or a salt thereof, n is 1, 2 or 3.
Claim 3
Dependent Claim
25 words
The composition as claimed in claim 1, wherein the stabiliser is selected from 2-pyridylacetic acid, pyridine-3,4-dicarboxylic acid, pyridine-2,5-dicarboxylic acid, 2-pyridyl-hydroxymethane sulphonic acid and salts thereof.
Claim 4
Dependent Claim
19 words
The composition as claimed in claim 1, wherein the radioactive label is selected from 35-S, 3-H, 32-P and 14-C.
Claim 5
Dependent Claim
17 words
The composition as claimed in claim 1, wherein the radioactively labelled organic compound is L-( 35 S)methionine.
Claim 6
Dependent Claim
16 words
The composition as claimed in claim 1, wherein the labelled organic compound is present in solution.
Claim 7
Dependent Claim
18 words
The composition as claimed in claim 5, wherein the concentration of stabilizer is from 1 to 300 mM.
Claim 8
Dependent Claim
18 words
The composition as claimed in claim 1, wherein the labelled organic compound is present in the freeze-dried state.
Claim 9
Dependent Claim
23 words
The composition as claimed in claim 7, wherein from 0.1 to 20 micromoles of stabilizer is present per millicurie of labelled organic compound.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-27 | 1992-06-27 | 1992-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-27 | 1996-06-27 | 1996-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-27 | 2000-06-27 | 2000-12-27 | $7700.00 | Window Closed / Lapsed |