US4847159A
Expired / Lapsed
US
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Substrates coated with organo-silanes that are sterically-protected
Assignee: Fleet Capital Corp
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Filing: 1987-11-10
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Granted: 1989-07-11
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Expires: 2007-11-10
Abstract
Abstract This invention involves unique compositions consisting of substrates coated with organo-silanes that are sterically protected by a single bulky group. This material consists of an appropriate reactive solid to which is attached a silane whose silicon stom is bonded to a functional group that contains a dimethyl-substituted tertiary carbon.
Inventors
- 👤 Joseph L. Glajch
- 👤 Joseph J. Kirkland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:55
CPC Classifications
C; C08; C08J; C08J7/00; C08J7/12; B; B01; B01J; B01J20/00; B01J20/02; B01J20/0203; B01J20/0218; B01J20/0251; B01J20/06; B01J20/10; B01J20/103; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/28054; B01J20/28057; B01J20/28078; B01J20/28083; B01J20/281; B01J20/286; B01J20/287; B01J20/288; B01J20/30; B01J20/3071; B01J20/3078; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3225; B01J20/3227; B01J20/3231; B01J20/3234; B01J20/3236; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3265; B01J20/3268; B01J20/327; C09; C09C; C09C1/00; C09C1/28; C09C1/30; C09C1/3081; B01J2220/00; B01J2220/50; B01J2220/54; B01J2220/58; C01; C01P; C01P2002/00; C01P2002/70; C01P2002/74; C01P2002/80; C01P2002/84; C01P2002/86; C01P2002/87; C01P2004/00; C01P2004/80; C01P2006/00; C01P2006/90; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2993; Y10T428/2995; Y10T428/2996; Y10T428/2998; Y10T428/31504; Y10T428/31551; Y10T428/31609; Y10T428/31612; Y10T428/31652; Y10T428/31663
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
94 words
A stable support structure comprising a substrate and a monofunctional silane containing a single sterically-protecting, dimethyl-substituted, tertiary carbon moiety attached to the silicon atom of the silane and additional functional groups, R, R 1 , and R 2 , covalently attached to the substrate, the silane being as follows: ##STR4## where R, R 1 and R 2 are alkane, substituted alkane, alkene, substituted alkene, aryl or substituted aryl, but specifically excluded are structures where R=R 1 =R 2 =CH 3 ; and A=a surface group of the substrate to which the silane is attached.
Claim 2
Dependent Claim
94 words
A stable support structure comprising a substrate and a monofunctional silane containing a single sterically-protecting, dimethyl-substituted, tertiary carbon moiety attached to the silicon atom of the silane and additional functional groups, R, R 1 , and R 2 , covalently attached to the substrate, the silane being as follows: ##STR4## where R, R 1 and R 2 are alkane, substituted alkane, alkene, substituted alkene, aryl or substituted aryl, but specifically excluded are structures where R=R 1 =R 2 =CH 3 ; and A=a surface group of the substrate to which the silane is attached.
Claim 3
Dependent Claim
21 words
The support structure of claim 1 in which the substrate is a hydrated metal oxide, a hydrated metalloid-oxide, or organic polymer.
Claim 4
Dependent Claim
28 words
The support structure of claim 2 in which the substrate also includes a plastic which will flow under an applied stress and is stable to normal reaction temperatures.
Claim 5
Dependent Claim
21 words
The support structure of claim 2 in which the metal oxide and metalloid oxide substrates include silica, chromia and tin oxide.
Claim 6
Dependent Claim
16 words
The support structure of claim 2 in which the substrate is rigid material coated with silica.
Claim 7
Dependent Claim
35 words
The support structure of claim 1 in which the protecting groups are able to closely pack around its hydrolytically unstable --Si--O-- groups of the silane attached to the substrate to protect this bond during use.
Claim 8
Dependent Claim
35 words
The support structure of claim 2 in which the protecting groups are able to closely pack around its hydrolytically unstable --Si--O-- groups of the silane attached to the substrate to protect this bond during use.
Claim 9
Dependent Claim
12 words
The support structure of claim 7 wherein the R groups are different.
Claim 10
Dependent Claim
24 words
A stable support structure for peptide synthesis comprising a silica substrate, and a silane, arrange as follows: ##STR5## covalently attached to the silica substrate.
Claim 11
Dependent Claim
24 words
A stable support structure for peptide synthesis comprising a silica substrate, and a silane, arrange as follows: ##STR5## covalently attached to the silica substrate.
Claim 12
Dependent Claim
17 words
The support structure of claim 1 wherein R, R 1 , or R 2 =--CH=CH 2 .
Claim 13
Dependent Claim
12 words
The use of the structure of claim 1 as a chromatographic support.
Claim 14
Dependent Claim
18 words
The support structure of claim 1 wherein the R 1 or R 2 -group includes as ion-exchange group.
Claim 15
Dependent Claim
26 words
The support structure of claim 1 wherein the R 1 or R 2 -group includes a site for attachment of a ligand useful in affinity chromatography.
Claim 16
Dependent Claim
21 words
The support structure of claim 1 wherein the R 1 or R 2 -group includes a site for attachment of catalysts.
Claim 17
Dependent Claim
26 words
The support structure of claim 1 wherein the R 1 or R 2 -group provides hydrophobic binding sites suitable for reverse-phase or hydrophobic in action chromatography.
Claim 18
Dependent Claim
23 words
The support structure of claim 1 wherein the R 1 or R 2 -group provides hydrophilic sites suitable for use in size-exclusion chromotography.
Claim 19
Dependent Claim
22 words
The support structure of claim 12 wherein the ion-exchange group is a weak anion-exchange, strong anion-exchange, weak cation-exchange or strong cation-exchange group.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |