Patent US3585482A successfully refreshed from Google Patents.
US4863968A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of treating gout with chalcone derivatives
Assignee: Aventis Pharmaceuticals Inc
•
Filing: 1988-12-14
•
Granted: 1989-09-05
•
Expires: 2008-12-14
Abstract
Abstract Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used as antigout agents. The chalcone derivatives are also reported to inhibit the destruction of the myelin sheath in the central nervous system of multiple sclerosis patients and are thus useful in controlling the progressive nature of the disease.
Inventors
- 👤 Michael L. Edwards
- 👤 Sai P. Sunkara
- 👤 David M. Stemerick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
72 words
A method for treating gout which comprises administering, to a patient in need thereof, an anti-gout amount of a chalcone derivative of the structure: ##STR4## wherein Ar is a 2,5-dimethoxyphenyl, 2,3,4-trimethoxyphenyl, or 3,4,5-trimethoxyphenyl substituent; R 1 is a hydrogen, (C 1 -C 4 )alkyl, chloro, or bromo substituent; and R 2 is --N(R) 2 or --NHCOR wherein R is a (C 1 -C 4 )alkyl substituent or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
72 words
A method for treating gout which comprises administering, to a patient in need thereof, an anti-gout amount of a chalcone derivative of the structure: ##STR4## wherein Ar is a 2,5-dimethoxyphenyl, 2,3,4-trimethoxyphenyl, or 3,4,5-trimethoxyphenyl substituent; R 1 is a hydrogen, (C 1 -C 4 )alkyl, chloro, or bromo substituent; and R 2 is --N(R) 2 or --NHCOR wherein R is a (C 1 -C 4 )alkyl substituent or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
16 words
A method of claim 1 wherein R 1 is a (C 1 -C 4 ) substituent.
Claim 4
Dependent Claim
12 words
A method of claim 1 wherein R 1 is a methyl substituent.
Claim 5
Dependent Claim
13 words
A method of claim 3 wherein R 2 is a --N(R) 2 .
Claim 6
Dependent Claim
11 words
A method of claim 4 wherein R is a methyl substituent.
Claim 7
Independent Claim
14 words
A method of any one of claims 1-5 wherein Ar is a 2,5-dimethoxyphenyl substituent.
Claim 8
Dependent Claim
24 words
A method of claim 1 wherein R 1 is a methyl substituent, R 2 is a dimethylamino substituent, and Ar is a 2,5-dimethoxyphenyl substituent.
References Cited (Backward Citations)
GB943266A
Cited
US3729313A
Cited
US3808006A
Cited
DE2558813A1
Cited
US4054682A
Cited
US4367280A
Cited
US4162162A
Cited
US4290870A
Cited
US4279930A
Cited
EP0013960A1
Cited
US4605674A
Cited
EP0028305A1
Cited
GB2081716A
Cited
US4753965A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-04 | 1993-03-06 | 1993-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-04 | 1997-03-06 | 1997-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-04 | 2001-03-06 | 2001-09-05 | $7700.00 | Window Closed / Lapsed |