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US4864020A
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Monoclonal antibodies and cell lines for parathyroid tissue-specific antigen parathyroid-specific
Assignee: Washington University in St. Louis
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Filing: 1985-12-13
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Granted: 1989-09-05
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Expires: 2005-12-13
Abstract
Abstract Monoclonal antibodies specific for an antigen present on the surface of parathyroid tissue are useful in imaging such tissue when conjugated to suitable label. The antibodies of the invention bind exclusively to parathyroid surfaces and do not bind to other tissues. The antibodies are useful in establishing the location of the parathyroid whether in its normal location or in ectopic placements. An exemplary monoclonal has been deposited at the American Type Culture Collection and has accession number ATCC No. HB9917.
Inventors
- 👤 William G. Cance
- 👤 Joseph M. Davie
- 👤 Samuel A. Wells, Jr.
- 👤 William G. Dilley
- 👤 Michael J. Welch
- 👤 Jeremiah J. Morrissey, IV
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:02
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/26; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1024; A61K2123/00; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/808; Y10S530/809; Y10S530/863; Y10S530/864; Y10S530/866
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
40 words
Monoclonal antibodies specifically immunoreactive with a human parathyroid tissue-specific antigen not secreted by said gland, wherein said antibodies are not immunoreactive with other human tissue, and which antibodies are cross-reactive with antibodies secreted by the hybridoma BB5-G1, ATCC No. HB9917.
Claim 2
Dependent Claim
40 words
Monoclonal antibodies specifically immunoreactive with a human parathyroid tissue-specific antigen not secreted by said gland, wherein said antibodies are not immunoreactive with other human tissue, and which antibodies are cross-reactive with antibodies secreted by the hybridoma BB5-G1, ATCC No. HB9917.
Claim 3
Dependent Claim
10 words
The antibodies of claim 1 which are of class IgM.
Claim 4
Dependent Claim
10 words
The antibodies of claim 1 which are of class IgG1.
Claim 5
Dependent Claim
11 words
Subfragments of the antibodies of claim 1 which retain antigen specificity.
Claim 6
Dependent Claim
12 words
The subfragments of claim 4 which are Fab or F(ab') 2 subfragments.
Claim 7
Dependent Claim
11 words
An immortalized cell line which secretes monoclonal antibodies of claim 1.
Claim 8
Dependent Claim
11 words
The immortalized cell line of claim 45 which is a hybridoma.
Claim 9
Dependent Claim
28 words
The hybridoma of claim 7 which is prepared by fusing blood lymphocytes or spleen cells from mice immunized with isolated human parathyroid tissue with a murine myeloma line.
Claim 10
Dependent Claim
11 words
The hybridoma of claim 7 which is BB5-G1, ATCC No. HB9917.
Claim 11
Dependent Claim
10 words
The monoclonal antibodies of claim 1 covalently bound to label.
Claim 12
Dependent Claim
9 words
The subfragments of claim 4 covalently bound to label.
Claim 13
Dependent Claim
11 words
The monoclonal antibodies of claim 10 wherein the label is radioactive.
Claim 14
Dependent Claim
10 words
The subfragments of claim 11 wherein the label is radioactive.
Claim 15
Dependent Claim
14 words
The monoclonal antibodies of claim 12 wherein the label is I-125, In-111, or Tc-99.
Claim 16
Dependent Claim
13 words
The subfragments of claim 13 wherein the label is I-125, In-111, or Tc-99.
Claim 17
Dependent Claim
21 words
The monoclonal antibodies of claim 1 wherein said antibodies, when bound to the parathyroid gland, enhance the secretion of parathyroid hormone.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-04 | 1993-03-06 | 1993-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-04 | 1997-03-06 | 1997-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-04 | 2001-03-06 | 2001-09-05 | $7700.00 | Window Closed / Lapsed |