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US4872873A Expired / Lapsed US ⏱️ 0.0 years remaining

Controlled release bolus device

Assignee: Alza Corp
•
Filing: 1987-12-14
•
Granted: 1989-10-10
•
Expires: 2007-12-14
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Abstract

Abstract This invention relates to an improved controlled release bolus device wherein the improvement comprises attaching at the orifice a screen or insert which prevents blockage of the orifice by exogeneous materials, but does not vary the flow of medicament from the device.

Inventors

  • 👤 Joel R. Zingerman

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-26 19:45
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0068

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 170 words
An improved controlled release bolus comprising a semipermeable membrane defining a compartment, the compartment being divided into first and second portions by a moveable interface, the first compartment portion containing a swellable agent, the second compartment portion containing a medicament to be dispensed, a densifier within the second compartment adjacent said membrane and a passageway through the membrane and densifier connecting said second compartment portion with the exterior of the bolus, having a central axis and a diameter such that when the bolus is in contact with water, the semipermeable membrane allow water to pass therethrough which is imbibed by the swellable agent which forces the interface to move the medicament to be dispensed through the passageway, wherein the improvement comprises an insert of rigid film having a central axis which is placed coaxially within the passageway, said inset comprising from 2 to 6 arm members connected together at and extending radially form said central axis of said insert a distance of approximately one-half of the diameter of the passageway.
Claim 2
Dependent Claim 170 words
An improved controlled release bolus comprising a semipermeable membrane defining a compartment, the compartment being divided into first and second portions by a moveable interface, the first compartment portion containing a swellable agent, the second compartment portion containing a medicament to be dispensed, a densifier within the second compartment adjacent said membrane and a passageway through the membrane and densifier connecting said second compartment portion with the exterior of the bolus, having a central axis and a diameter such that when the bolus is in contact with water, the semipermeable membrane allow water to pass therethrough which is imbibed by the swellable agent which forces the interface to move the medicament to be dispensed through the passageway, wherein the improvement comprises an insert of rigid film having a central axis which is placed coaxially within the passageway, said inset comprising from 2 to 6 arm members connected together at and extending radially form said central axis of said insert a distance of approximately one-half of the diameter of the passageway.
Claim 3
Dependent Claim 17 words
The device of claim 1 wherein the rigid film insert extends substantially the length of the passageway.
Claim 4
Dependent Claim 19 words
The device of claim 2, wherein the rigid film insert extends at least half the length of the passageway.

References Cited (Backward Citations)

US3732865A Cited
US4425117A Cited
US4312347A Cited
US4326522A Cited
US4350271A Cited
US4416659A Cited
US4479796A Cited
US4624945A Cited
EP0164241A2 Cited
US4704118A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-10-09 1993-04-10 1993-10-10 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-10-09 1997-04-10 1997-10-10 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-10-09 2001-04-10 2001-10-10 $7700.00 Window Closed / Lapsed

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