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US4885296A
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1-piperazinylpyrimidine derivatives and application thereof in therapeutics and cosmetics
Assignee: L'Oréal SA
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Filing: 1987-12-01
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Granted: 1989-12-05
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Expires: 2007-12-01
Abstract
Abstract New compounds derived from 1-piperazinylpyrimidine derivatives, and their application in therapeutics and cosmetics, corresponding to the general formula: <IMAGE> (I) in which R represents an alkoxycarbonyl group containing from 1 to 3 carbon atoms in the alkoxy chain or alternatively a furoyl group, n being 0 or 1, and their addition salts with cosmetically or pharmaceutically acceptable acids.
Inventors
- 👤 Philippe Manoury
- 👤 Jean F. Grollier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 12:45
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/50; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/494; A61K8/4953; A61P; A61P43/00; A61Q; A61Q7/00; C07D405/00; C07D405/02; C07D405/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
40 words
Compounds corresponding to the formula (I): ##STR5## in which R represents an alkoxycarbonyl group having from 1 to 3 carbon atoms in the alkoxy chain or represents a furoyl group, n is 0 or 1, and their acid addition salts.
Claim 2
Dependent Claim
40 words
Compounds corresponding to the formula (I): ##STR5## in which R represents an alkoxycarbonyl group having from 1 to 3 carbon atoms in the alkoxy chain or represents a furoyl group, n is 0 or 1, and their acid addition salts.
Claim 3
Dependent Claim
19 words
Compounds according to claim 1, selected from the group comprising of ethyl 4-(2,4-diamino-6-pyrimidinyl)piperazinecarboxylate, 4-(2,4-diamino-6-pyrimidinyl)-1-(2-furoyl)piperazine, ethyl 4-(2,4-diamino-3-oxy-6-pyrimidinyl)piperazinecarboxylate and their hydrochlorides.
Claim 4
Dependent Claim
38 words
Composition to be used for the treatment of the scalp and hair for inducing and stimulating hair growth and for decreasing hair loss containing an excipient and effective amount of a compound according to claim 1 or 2.
Claim 5
Dependent Claim
31 words
Composition according to claim 3 wherein the compound of formula (I) is present in proportions of between 0.01 and 15 % by weight relative to the total weight of the composition.
Claim 6
Dependent Claim
17 words
Composition according to claim 4, wherein the the excipient consists of an aqueous, aqueous/alcoholic or alcoholic medium.
Claim 7
Dependent Claim
30 words
Process for inducing and stimulating hair growth and for decreasing hair loss comprising applying an effective amount of the composition of claim 3 to the hair or to the scalp.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-04 | 1993-06-05 | 1993-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-04 | 1997-06-05 | 1997-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-04 | 2001-06-05 | 2001-12-05 | $7700.00 | Window Closed / Lapsed |