Novel pyrrolidine-2-(1,3-dicarbonyl) derivatives, a process for their preparation, agents containing them, and their use

Claim 1

A compound of the formula I ##STR15## in which R 1 denotes hydrogen; (C 1 -C 6 )-alkyl; or (C 6 -C 12 )-aryl, said aryl being optionally substituted by one, two or three identical or different radicals selected from (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, halogen, nitro, hydroxyl, amino, (C 1 -C 4 )-alkylamino and di-(C 1 -C 4 )-alkylamino, or one (C 1 or C 2 )-alkylenedioxy; R 2 denotes hydrogen; (C 1 -C 6 )-alkyl; (C 6 -C 12 )-aryl; (C 6 -C 12 )-aryloxy; (C 7 -C 13 )-aroyl; hydroxyl or (C 1 -C 4 )-alkoxy, where said aryl, aryloxy and aroyl are in each case optionally substituted by one, two or three identical or different radicals selected from (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, halogen, nitro, hydroxyl, amino, (C 1 -C 4 )-alkylamino and di-(C 1 -C 4 )-alkylamino, or by one (C 1 or C 2 )-alkylenedioxy; or R 1 and R 2 together represent benzylidene in which the phenyl ring is optionally substituted by one, two or three identical or different radicals selected from (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, halogen, nitro, hydroxyl, amino, (C 1 -C 4 )-alkylamino and di-(C 1 -C 4 )-alkylamino, or by one (C 1 or C 2 )-alkylenedioxy; R 5 denotes hydrogen; (C 1 -C 6 )-alkyl; (C 6 -C 12 )-aryl-(C 1 -C 5 )-alkyl which is optionally substituted in the aryl part by one, two or three identical or different radicals selected from (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, halogen, nitro, hydroxyl, amino, (C 1 -C 4 )-alkylamino and di-(C 1 -C 4 )-alkylamino, or by one (C 1 or C 2 )-alkylenedioxy; R 6 denotes (C 1 -C 8 )-alkyl; (C 6 -C 12 )-aryl; (C 6 -C 12 )-aryl-(C 1 -C 6 )-alkyl; hydroxyl; (C 1 -C 8 )-alkoxy; (C 6 -C 12 )-aryloxy or (C 6 -C 12 )-aryl-(C 1 -C 6 )-alkoxy, where said aryl, aralkyl, aryloxy and arylalkoxy groups are in each case optionally substituted in the aryl part by one, two or three identical or different radicals selected from (C 1 -C 4 )-alkyl, (C 1 or C 2 )-alkoxy, halogen and nitro, or by one (C 1 or C 2 )-alkylenedioxy; or R 6 represents a radical of the formula --NR 7 R 8 in which R 7 and R 8 are identical or different and denote hydrogen; (C 1 -C 8 )-alkyl; (C 4 -C 10 )-cycloalkyl; (C 1 -C 4 )-alkyl-(C 4 -C 10 )-cycloalkyl; (C 6 -C 12 )-aryl; (C 6 -C 12 )-aryl-(C 1 -C 6 )-aryl; amino-(C 1 -C 8 )-alkyl; (C 1 -C 4 )-alkylamino-(C 1 -C 8 )-alkyl; di-(C 1 -C 4 )-alkylamino-(C 1 -C 8 )-alkyl; hydroxy-(C 1 -C 8 )-alkyl or (C 1 -C 4 )-alkoxy-(C 1 -C 8 )-alkyl, where said aryl and aralkyl groups are in each case optionally substituted in the aryl part by one, two or three identical or different radicals selected from (C 1 -C 4 )-alkyl, (C 1 or C 2 )-alkoxy, (C 1 -C 4 )-alkylamino, di-(C 1 -C 4 )-alkylamino, halogen, hydroxyl and amino, or by one (C 1 or C 2 )-alkylenedioxy; X denotes oxygen; imino or N-(C 1 -C 8 )-alkylimino; m is 0, 1, 2, 3, 4 or 5; and s is 0 or 1; or a physiologically acceptable salt thereof.