Patent US4957736A successfully refreshed from Google Patents.
US4957736A
Expired / Lapsed
US
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Composition for vaccines
Assignee: Sclavo SpA
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Filing: 1989-05-26
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Granted: 1990-09-18
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Expires: 2009-05-26
Abstract
Abstract The invention is concerned with the use of a compound analogous to tuftsin, having the formula (I) ##STR1## or of a pharmaceutically acceptable base-addition or acid-additon salt thereof, as an adjuvant in order to potentiate, in a living organism, the antibody response against either natural or synthetic antigens, as well as with the novel compositions for vaccines which comprise one or more of said antigens together with an adjuvating amount of the compound of formula (I) or of one of its addition salts.
Inventors
- 👤 Luciano Nencioni
- 👤 Piero Pileri
- 👤 Samuele Peppoloni
- 👤 Sergio Silvestri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:31
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0212; A; A61; A61P; A61P37/00; A61K; A61K39/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
69 words
A vaccine comprising one or more antigens of either natural or synthetic origins, together with an adjuvant amount of a compound of formula (I) ##STR4## wherein the absolute configuration of each carbon atom marked with an asterisk is the L-configuration, and the absolute configuration of the carbon atom of the malonyl residue is either the L- or the D-configuration; or with a pharmaceutically acceptable base-addition or acid-addition salt thereof.
Claim 2
Dependent Claim
69 words
A vaccine comprising one or more antigens of either natural or synthetic origins, together with an adjuvant amount of a compound of formula (I) ##STR4## wherein the absolute configuration of each carbon atom marked with an asterisk is the L-configuration, and the absolute configuration of the carbon atom of the malonyl residue is either the L- or the D-configuration; or with a pharmaceutically acceptable base-addition or acid-addition salt thereof.
Claim 3
Dependent Claim
14 words
Vaccine according to claim 1 wherein the antigen is of proteinic or glyco-proteinic type.
Claim 4
Dependent Claim
39 words
Vaccine according to claim 1 wherein as the adjuvant a mixture is used of diastereoisomers having absolute L-configuration at the carbon atoms marked with an asterisk, and L- and D-configuration at the asymmetrical carbon atom of the malonyl residue.
Claim 5
Dependent Claim
93 words
A vaccine comprising one or more antigens of either natural or synthetic origin derived from at least one member of the group consisting of pertussis, A, B and C meningitis, polysaccharide pneumococci, diphtheria, tetanus, hepatitis and chlorera; together with an adjuvant amount of a compound of formula (I) ##STR5## wherein the absolute configuration of each carbon atom marked with an asterisk is the L-configuration and the absolute configuration of the carbon atom of the malonyl residue is either the L- or the D-configuration or with a pharmaceutically acceptable base-addition or acid-addition salt thereof.
Claim 6
Dependent Claim
93 words
A vaccine comprising one or more antigens of either natural or synthetic origin derived from at least one member of the group consisting of pertussis, A, B and C meningitis, polysaccharide pneumococci, diphtheria, tetanus, hepatitis and chlorera; together with an adjuvant amount of a compound of formula (I) ##STR5## wherein the absolute configuration of each carbon atom marked with an asterisk is the L-configuration and the absolute configuration of the carbon atom of the malonyl residue is either the L- or the D-configuration or with a pharmaceutically acceptable base-addition or acid-addition salt thereof.
Claim 7
Dependent Claim
40 words
The vaccine according to claim 4 wherein as the adjuvant a mixture is used of diastereoisomers having absolute L-configuration at the carbon atoms marked with an asterisk, and L- and D-configurations at the asymmetrical carbon atom of the malonyl residue.
References Cited (Backward Citations)
US4353823A
Cited
US4390528A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-17 | 1994-03-19 | 1994-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-17 | 1998-03-19 | 1998-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-17 | 2002-03-19 | 2002-09-18 | $7700.00 | Window Closed / Lapsed |